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AKT1 — GP1BB

Text-mined interactions from Literome

Yin et al., Blood 2008 : Akt1 and Akt2 play important roles in early GPIb-IX signaling independent of Syk, adenosine diphosphate ( ADP ), or thromboxane A2 ( TXA2 ), in addition to their recognized roles in ADP- and TXA2 dependent secondary amplification pathways ... Thus, Akt1 and Akt2 mediate GPIb-IX signaling via the cGMP dependent signaling pathway
Shumoogam et al., IDrugs 2010 (Hematologic Neoplasms...) : This conference report highlights selected presentations on hematological malignancies, lymphoma, Hodgkin lymphoma, AKT inhibitors for the treatment of chronic lymphocytic leukemia, and the activation of GPIb with von Willebrand factor
Delaney et al., Arterioscler Thromb Vasc Biol 2012 : von Willebrand factor/GPIb-IX interaction sequentially activates the Src family kinase Lyn (SFK), phosphoinositide 3-kinase (PI3K), and Akt , leading to activation of integrin a ( IIb ) ß ( 3 ) and integrin dependent stable platelet adhesion and aggregation ... Furthermore, GPIb induced activation of Akt was abolished in Rac1-deficient platelets, suggesting that Rac1 is upstream of the PI3K/Akt pathway