Gene interactions and pathways from curated databases and text-mining

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KRAS — RAF1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Roy et al., Mol Cell Biol 2002 : Inhibition of endocytosis by dominant interfering dynamin-K44A blocked H-Ras but not K-Ras mediated PC12 cell differentiation and selectively inhibited H-Ras- but not K-Ras mediated Raf-1 activation in BHK cells ... H-Ras- but not K-Ras mediated Raf-1 activation was also selectively dependent on phosphoinositide 3-kinase activity
Moretó et al., Cell Signal 2009 (MAP Kinase Signaling System) : Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling ... In the present study, we show that CaM has completely opposite effects on K-Ras mediated Raf-1 activation
Hoogwater et al., Gastroenterology 2010 (Colorectal Neoplasms...) : Oncogenic K-Ras and its effector Raf1 convert death receptors into invasion inducing receptors by suppressing the ROCK/LIM kinase pathway, and this is essential for K-Ras/Raf1-driven metastasis formation
Yan et al., J Biol Chem 1998 : Thus, Ki-Ras both recruits Raf-1 to the plasma membrane more efficiently than Ha-Ras and is a more potent activator of membrane recruited Raf-1 than Ha-Ras