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CASP7 — ROCK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Coleman et al., Nat Cell Biol 2001
:
Membrane blebbing during apoptosis results from
caspase mediated
activation of
ROCK I
Sebbagh et al., Nat Cell Biol 2001
:
Thus,
activation of
ROCK I by
caspase-3 seems to be responsible for bleb formation in apoptotic cells
Ueda et al., J Biol Chem 2001
:
Galpha11 induces
caspase mediated proteolytic activation of Rho associated kinase,
ROCK-I , in HeLa cells ... Galpha11 induces
caspase mediated proteolytic activation of Rho associated kinase,
ROCK-I , in HeLa cells
Ueda et al., Exp Cell Res 2004
:
We have previously reported that expression of the constitutively active mutant of Galpha11 or stimulation of m1 muscarinic acetylcholine receptor induced proteolytic
activation of
Rho associated kinase (ROCK-I) by
caspase and apoptosis in HeLa cells
Croft et al., J Cell Biol 2005
:
Membrane blebbing during the apoptotic execution phase results from
caspase mediated cleavage and activation of
ROCK I
Söderström et al., J Cell Sci 2005
:
CD95 activated RhoA exclusively in the type II cell, whereas
ROCK activation was
caspase dependent in the type I cell
Chang et al., Proc Natl Acad Sci U S A 2006
(Disease Models, Animal...) :
ROCK-1 dependent
caspase-3 activation was coupled with the activation of PTEN and the subsequent inhibition of protein kinase B ( Akt ) activity, all of which was attenuated by siRNA directed against ROCK-1 expression
Koyanagi et al., J Neurosci Res 2008
:
Membrane blebbing, which is an early morphological sign of apoptosis ; cleavage of
caspase-3 ; and release of cytochrome c from the mitochondria are also
reduced by
ROCK inhibition
Gabet et al., Cell Death Differ 2011
:
Therefore, in this differentiation system, final maturation occurs independently of SCF signaling through
caspase induced
ROCK-1 kinase activation
Iwasaki et al., Mol Biol Cell 2013
:
During apoptosis,
caspase-3 activated
Rho associated protein kinase I triggers hyperphosphorylation of myosin II, leading to membrane blebbing