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DHFR — E2F1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Fry et al., J Biol Chem 1999
:
Activation of the murine
dihydrofolate reductase promoter by
E2F1 ... Previously, we have demonstrated that cell cycle regulation of murine
dihydrofolate reductase (dhfr) expression
requires E2F mediated activation of the dhfr promoter in S phase
Sahin et al., International journal of biological sciences 2010
:
For example,
E2F-1 acts as part of the repression complex with pRB in the expression of
DHFR , b-myb, TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle ... For example,
E2F-1 acts as part of the repression complex with pRB in the expression of
DHFR , b-myb, TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle
Blake et al., Mol Cell Biol 1989
:
Thus, the interaction of
E2F with the DHFR promoter is
required for efficient expression of the
DHFR gene
Margolis et al., J Virol 1995
:
Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with
E2F dependent activation of
dihydrofolate reductase transcription
Slansky et al., Mol Cell Biol 1993
:
In this study, we focused on the
role of
E2F in the growth regulation of
DHFR
Vallian et al., Mol Cell Biol 1998
:
Furthermore, cotransfection of PML specifically repressed Sp1, but not the
E2F1 mediated activity of the
dihydrofolate reductase promoter