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EPHB2 — SPR
Text-mined interactions from Literome
Yamaguchi et al., Cancer Chemother Pharmacol 2005
(Glioblastoma) :
Using either the epidermal growth factor receptor (EGFR) kinase inhibitor, AG 1478, or a small interfering RNA ( siRNA ) directed against human EGFR, we found that transactivation of EGFR by
SPR is only marginally
involved in SP-dependent
ERK1/2 phosphorylation
Yamaguchi et al., Brain Tumor Pathol 2005
(Astrocytoma) :
At the molecular level, stimulation of
SPR in human U373 MG glioblastoma cells
results in phosphorylation of mitogen activated protein kinases
ERK1/2 ... Examination of the underlying mechanism reveals that
SPR mediates
ERK1/2 phosphorylation in a calcium dependent manner ... Surprisingly, blockade of epidermal growth factor receptor (EGFR), which is transactivated by SPR, has a minimal effect on
SPR mediated
ERK1/2 phosphorylation ... However,
SPR mediated
ERK1/2 phosphorylation is significantly reduced by the Src kinase inhibitor PP2