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HIF1A — IGF2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IGF2 → HIF1A (increases, IGF2 Activity)
  Evidence: Several growth factors, most notably insulin-like growth factor-2 (IGF2) and transforming growth factor-a (TGF-a), are also HIF-1 target genes. Binding of these factors to their cognate receptors the insulin-like growth factor 1 receptor (IGF1R) and epidermal growth-factor receptor (EGFR), respectively activates signal-transduction pathways that lead both to HIF-1a expression (as described above) and to cell proliferation survival. HIF-1 therefore contributes to autocrine-signalling pathways tha...

Text-mined interactions from Literome

Feldser et al., Cancer Res 1999 : We demonstrate that insulin, insulin-like growth factor (IGF)-1, and IGF-2 induce expression of HIF-1alpha , which is required for expression of genes encoding IGF-2, IGF binding protein (IGFBP)-2 and IGFBP-3
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Furthermore, IGF-1 enhanced HIF-1alpha protein levels and HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA
Tanaka et al., Cancer Res 2006 (Anoxia...) : Treating the HCC cells with IGF-II or epidermal growth factor (EGF) up-regulated both phospho-Akt and HIF-1alpha, whereas inhibition of IGF-II or EGF signaling down-regulated them both, suggesting that IGF-II and EGF can, at least in part, mediate the activation of Akt and HIF-1alpha
Pringle et al., Placenta 2007 : In conclusion, Hif-1alpha and Hif-2alpha are differentially regulated by oxygen and IGF-II in cultured trophoblast cells and asHif-1alpha may mediate the response to prolonged hypoxia in murine trophoblasts
Thomas et al., Prostate 2009 (Prostatic Neoplasms) : Additionally, inhibition of IGF-2 activity markedly attenuated the serum deprivation mediated increase in IGF-IR and Akt activation, HIF-1alpha expression, and also its own transcription, suggesting autocrine regulation of HIF-1alpha expression via IGF-2 ... Furthermore, HIF-1alpha suppression attenuated the serum deprivation mediated increase in Akt and IGF-IR activation
Lawton et al., Oxidative medicine and cellular longevity 2010 : Hypoxia inducible factor-1 alpha ( HIF-1a ) regulates cell migration, signals through Notch, and is regulated by hypoxia/oxidative stress, insulin/IGF signaling, and factor inhibiting HIF-1a (FIH) hydroxylation