Liang et al., Zhonghua Shao Shang Za Zhi 2007
:
To explore the effect of epidermal growth factor (EGF) on apoptosis induced by TNF-alpha and the expression of PPARbeta in HaCaT keratinocytes ... EGF can inhibit the apoptosis of HaCaT keratinocytes induced by TNF-alpha, and it can also increase the expression of PPARbeta Liang et al., Exp Cell Res 2008
:
Electrophoretic mobility shift assay ( EMSA ) revealed that EGF significantly increased PPARbeta/delta binding activity in HaCaT keratinocytes ... These results demonstrate that EGF induces PPARbeta/delta expression in a c-Jun dependent manner and PPARbeta/delta plays a vital role in EGF stimulated proliferation of HaCaT cells
Zeng et al., Cancer Res 2008
(Adenoma...) :
The expression of PPARdelta was induced coordinately with proliferation in primary human thyroid cells by the activation of serum, thyroid stimulating hormone/cyclic AMP, or epidermal growth factor/mitogen activated protein kinase mitogenic signaling pathways
Liang et al., Wound Repair Regen 2008
:
Here, we showed that EGF up-regulated the DNA binding and transcriptional regulation activities of PPARbeta