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CFTR — NPY6R
Text-mined interactions from Literome
Dahan et al., Pflugers Arch 2001
(Cystic Fibrosis) :
Phosphatases that deactivate CFTR have yet to be identified definitively at the molecular level, however
CFTR is
regulated by a membrane bound form of protein
phosphatase-2C ( PP2C ) in several cell types ... Understanding the
regulation of
CFTR by
PP2C is a priority due to its potential as a target for pharmacotherapies in the treatment of cystic fibrosis
Fischer et al., Pflugers Arch 1998
:
We propose that in order to
regulate CFTR in an intact cell,
PP2B may require a selective subcellular localization to become active
Luo et al., Am J Physiol 1998
:
Adding PP2A,
PP2C , or alkaline phosphatase to excised patches
reduced CFTR channel activity by > 90 % but did not abolish it completely