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NOS2 — PTX3

Text-mined interactions from Literome

Beshay et al., Clin Immunol 2001 (Autoimmune Diseases...) : ROL and PTX suppressed inducible NO synthase at the mRNA level
Hoebe et al., Biochem Pharmacol 2001 : In contrast, PTX potentiated NO production and the expression of inducible nitric oxide synthase (iNOS) in hepatocytes after stimulation with LPS
Kim et al., Gen Pharmacol 2000 : In the present study, we observed that pentoxifylline ( PTX ) significantly augmented the nitric oxide ( NO ) production and the iNOS gene expression by interleukin-1beta (IL-1beta) stimulated vascular smooth muscle cells ( VSMCs ) ... These results suggest that enhancing effects of PTX on the iNOS gene expression in the IL-1beta stimulated VSMCs is mediated predominantly through the activation of NF-kappaB via cAMP dependent PKA pathway
Park et al., Int J Lepr Other Mycobact Dis 2001 : Western blot analyses demonstrated that iNOS was suppressed by PTX
Trajković et al., Immunology 1997 : The aim of this study was to investigate effects of pentoxifylline ( PTX ) , a phosphodiesterase inhibitor with immunomodulatory properties, on NO production and inducible NO synthase (iNOS) mRNA expression in rat astrocytes and macrophages
Vaziri et al., Am J Physiol 1998 (Kidney Failure, Chronic) : Calcium channel blockade and PTX lowered blood pressure, increased urinary NOX, and enhanced vascular NOS activity, as well as eNOS and iNOS protein expressions in the tested tissues