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PPARG — SIRT3
Text-mined interactions from Literome
Das et al., Prostaglandins Leukot Essent Fatty Acids 2005
(Diabetes Mellitus, Type 2...) :
In addition,
SIRT1 repressed
PPAR-gamma , and overexpression of SIRT1 attenuated adipogenesis, and upregulation of SIRT in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span
Zhang et al., J Bone Miner Res 2010
(Bone Diseases, Metabolic) :
In contrast, adipocyte formation and
Ppar-gamma expression in cultures were increased, and expression of the polycomb protein
sirtuin ( Sirt1 ) was
reduced