◀ Back to PPARG
AKT1 — PPARG
Text-mined interactions from Literome
Goetze et al., Hypertension 2002
:
Both
PPARgamma-ligands inhibited leptin stimulated
Akt and eNOS phosphorylation, but neither attenuated ERK 1/2 activation in response to leptin
Peng et al., Genes Dev 2003
(Abnormalities, Multiple...) :
Specifically,
Akt1 and Akt2 are
required for the induced expression of
PPARgamma , the master regulator of adipogenesis, establishing a new essential role for Akt in adipocyte differentiation
Wang et al., Cell Res 2005
:
We found that arsenic trioxide induced the expression and the phosphorylation of
Akt/PKB and it
inhibited the interaction between Akt/PKB and
PPARgamma
Lin et al., J Clin Endocrinol Metab 2005
:
RSG activation of
PPAR-gamma resulted in downstream activation of the serine/threonine protein kinase
Akt , an outcome that was inhibited by a specific phosphatidylinositol 3-kinase inhibitor, which ablated RSG protection against h-IAPP induced islet cell apoptosis
Zhou et al., Mol Cell Biochem 2009
:
Phosphatidylinositol
3-kinase/AKT ( PI-3 K/AKT ) and extracellular signal regulated kinase ( ERK ) signaling pathways
mediate the leptin induced inhibition of
PPARgamma gene expression
Kim et al., Biochem Biophys Res Commun 2010
:
Here we showed that cAMP induced activation of protein kinase A (PKA) and
Akt is
essential for the transcriptional activation of
PPAR-gamma ... In addition, IBMX induced
PPAR-gamma transcriptional activity was
blocked by
PI3K/Akt , PKA, or Rap1 inhibitors ... These results indicate that both PKA and
Akt signaling pathways are
required for transcriptional activation of
PPAR-gamma , suggesting post-translational activation of PPAR-gamma might be critical step for adipogenic gene expression