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MMP9 — RAC1
Text-mined interactions from Literome
Zhuge et al., J Biol Chem 2001
(Carcinoma, Squamous Cell...) :
The
Rac1 dependent MMP-2 activation occurred in a cell associated fashion and
required MMP activities
Binker et al., Biochem Biophys Res Commun 2009
(Pulmonary Disease, Chronic Obstructive) :
LPS stimulated MUC5AC production involves
Rac1 dependent
MMP-9 secretion and activation in NCI-H292 cells
Murthy et al., J Biol Chem 2010
(MAP Kinase Signaling System...) :
To investigate the contribution of aberrant matrix degradation, we addressed the
role of
Rac1 in regulating expression of macrophage-specific
MMP-9 ( matrix metalloproteinase-9 ) ...
Rac1 regulates
MMP-9 transcription via mitochondrial H ( 2 ) O ( 2 ) generation, providing a potential mechanism by which Rac1 null mice fail to develop pulmonary fibrosis
Chan et al., Cardiovasc Ther 2012
(Diabetes Mellitus) :
Under high glucose conditions, simvastatin dose-dependently inhibited VSMC migration, decreased PI3K/Akt pathway activity, reduced c-Raf and Ras expression, increased RhoB but not RhoA,
Rac1 , and Cdc2 expression, dose-dependently
inhibited MMP-2, but not
MMP-9 , activity, and dose-dependently inhibited NF-?B activity
Murthy et al., Biochem J 2012
:
We determined the
effects of
Rac1 and ERK on
MMP-9 expression driven by SP-1WT ( wild-type ) and the SP-1 mutants T578A, S586A and S587A ... However, constitutively active
Rac1 suppressed
MMP9 promoter activity in cells expressing SP-1WT, SP-1T578A and SP-1S587A, but not SP-1S586A
Stallings-Mann et al., Sci Transl Med 2012
(Adenocarcinoma...) :
We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by
MMP induced expression of
Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence
Serratì et al., Arthritis Rheum 2013
(Scleroderma, Systemic) :
Motility increase required
Rac1 activation and RhoA inhibition and was
inhibited by an
MMP inhibitor