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MMP2 — PTGS2

Text-mined interactions from Literome

Pan et al., FEBS Lett 2001 (Lung Neoplasms) : Additionally, this COX-2 inhibitor attenuated the degrading activity of MMP-2 as demonstrated by gelatin zymography
Dohadwala et al., J Biol Chem 2002 (Carcinoma, Non-Small-Cell Lung...) : Genetic inhibition of tumor COX-2 led to diminished matrix metalloproteinase (MMP)-2 , CD44, and EP4 receptor expression and invasion
Dickens et al., J Pediatr Hematol Oncol 2003 (Bone Neoplasms...) : Tumor development and growth were measured following treatment with a COX-2 inhibitor ( celecoxib ), an MMP inhibitor ( doxycycline ), or both
Ito et al., Biochem Biophys Res Commun 2004 (Neoplasm Invasiveness...) : In this study, we investigated the role of COX-2 in fibronectin induced up-regulation of rhabdomyosarcoma matrix metalloproteinase (MMP)-2 activity and cellular invasiveness
Sivula et al., Breast Cancer Res Treat 2005 (Breast Neoplasms...) : A direct link between COX-2 and MMP-2 may exist, since inhibition of COX-2 activity can result in reduction of MMP-2 expression and activity
Okada et al., Anticancer Res 2005 : Bis-EUG, MMP and bis-MMP inhibited COX-2 gene expression at concentrations of 300 microM, 500 microM and 500 microM, respectively
Mrena et al., J Clin Pathol 2006 (Adenocarcinoma...) : In gastric cancer tumour growth is apparently induced by COX-2 , and invasion is mediated by MMP-2
Spinella et al., Cancer Res 2007 (Melanoma...) : Moreover, COX-1/COX-2 inhibitors block ET-induced PGE ( 2 ) and VEGF secretion, matrix metalloproteinase ( MMP ) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties
Lee et al., Exp Mol Med 2007 (Bone Neoplasms...) : Selective COX-2 inhibitors, NS-398 and celecoxib, inhibited cell proliferation and abrogated the enhanced mobility, invasiveness and MMP activities induced by COX-2 overexpression
Jeong et al., Anticancer Res 2010 (Lung Neoplasms...) : Importantly, cPLA2, and 5-LO, and COX-2 inhibitors reduced platelet activating factor induced angiogenesis in an in vivo mouse model employing Matrigel injected subcutaneously, and also reduced expression of MMP-2 and MMP-9 in the lungs
Yao et al., J Exp Clin Cancer Res 2011 (Neoplasms, Experimental...) : The results of RT-PCR and western blot showed that down-regulation of COX-2 might inhibit VEGF, Flt-1, Flk-1/KDR, angiopoietin-1, tie-2, MMP2 and OPN
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1, whereas the secretion of invasion promoting MMP-2 remained unaffected
Lee et al., Anticancer Res 2011 (Breast Neoplasms...) : Moreover, expression of matrix metalloproteinase ( MMP-2 ) mediating the transmigration was induced in HBECs by COX-2 after co-culture with breast cancer cells
Khan et al., J Immunol 2012 : In the current study, we determined whether MMP induced cyclooxygenase-2 expression was coupled to the expression of prostaglandin E synthase family members