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CA2 — IL6
Text-mined interactions from Literome
Carlstedt et al., Biosci Rep 1999
:
Neither
IL-6 nor TNF-alpha,
affected cytoplasmic
Ca2+ of the cells
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 1999
:
The depletion of extracellular
Ca2+ by EGTA
reduced the PGD2 induced
IL-6 synthesis
Junn et al., J Immunol 2000
:
Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells :
involvement of hydrogen peroxide and
Ca2+ in TGF-beta 1-induced
IL-6 expression
Liu et al., Proc Soc Exp Biol Med 2000
(Calcium Signaling) :
Ca2+ release from intracellular stores was strongly
stimulated by acetylcholine (ACh) and ATP, but not by norepinephrine ( NA ), epidermal growth factor (EGF),
interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFalpha)
Jeong et al., Cell Signal 2002
(Calcium Signaling) :
These observations demonstrate that the intracellular
Ca2+ may
play an important role in IgE induced TNF-alpha and
IL-6 secretion from mast cells via IKKbeta activation
Söderblom et al., Scand J Infect Dis 2003
(Inflammation) :
Specifically, the proinflammatory cytokine
interleukin-6 (IL-6) and chemokine IL-8 were
induced by HlyA induced
Ca2+ oscillations
Lee et al., Proc Natl Acad Sci U S A 2003
(Calcium Signaling) :
These findings support a model in which
Ca2+ binding to the C-terminal EF-hands of preassociated CaM
initiates CDF via interaction with the IQ-like domain
Tanaka et al., Eur J Immunol 2005
:
Ca2+ influx
mediated histamine synthesis and
IL-6 release in mast cells activated by monomeric IgE
Zi et al., Zhonghua Nan Ke Xue 2006
:
IL-6 could induce AR by stimulating the activity of acrosin and SOD in human sperm, which also involves the activation of PKC, and
requires the presence of extracellular
Ca2+
Keller et al., Cytokine 2006
:
Here we investigated whether skeletal myocytes produce
IL-6 in a
Ca2+/calcineurin dependent manner, and whether TNF-alpha, an inducer of IL-6, is affected by these stimuli
Nie et al., J Physiol Sci 2007
(Calcium Signaling...) :
We confirmed that a high-K ( + ) and
high-Ca(2) ( + ) could
induce an increase of the intracellular Ca ( 2+ ) concentration and subsequent
CDF and CDI
Wang et al., J Biol Chem 2009
(Calcium Signaling) :
Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate
interleukin-1 induced
Ca2+ signaling
Kodama et al., Meikai Daigaku Shigaku Zasshi 1990
(Bone Resorption...) :
Among several bioactive substances known as coupling factors, transforming growth factor-beta ( TGF-beta ),
interleukin-1 (IL-1), and prostaglandin ( PG ) E1 and E2
increased not only the activity of alkaline phosphatase but also the rate of incorporation of
45Ca2+ into ROS 17/2.8 during a 3-day culture : the former two factors are known to be formed at the site where bone is resorbed, while PG 's are known as one of the factors involved in bone resorption
Kodama et al., Meikai Daigaku Shigaku Zasshi 1989
(Bone Resorption) :
The
effects of
interleukin 1, transforming growth factor-beta ( coupling factors ), prostaglandin E1, and prostaglandin E2 on incorporation of
45Ca2+ and on alkaline phosphatase activity were studied using cultured ROS 17/2.8 cells, one of cell lines derived from rat osteosarcoma
Qiu et al., Biochem Pharmacol 1994
:
In the present study, we investigated the
effects of lymphokines
[interleukin-4 (IL-4), interleukin-2 (IL-2) ] and other pharmacologic agents [ lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate ( PMA ) ] on HTMT induced
Ca2+ and IP responses in non rosetted cells
de Wit et al., Br J Haematol 1994
:
Using the human monocytic cell line Mono Mac 6 we studied the
involvement of
Ca2+ , protein kinase A (PKA), and protein kinase C ( PKC ) dependent pathways in the regulation of M-CSF and
IL-6 gene expression
Kozawa et al., Arch Biochem Biophys 1997
:
The depletion of extracellular
Ca2+ by EGTA
suppressed the thrombin induced
IL-6 synthesis
Kumar et al., Int J Immunopharmacol 1997
:
Effect of prolactin on nitric oxide and
interleukin-1 production of murine peritoneal macrophages :
role of
Ca2+ and protein kinase C
Kozawa et al., Cell Signal 1997
:
The depletion of extracellular
Ca2+ by EGTA
suppressed the bFGF induced
IL-6 synthesis
Kozawa et al., Bone 1998
:
The depletion of extracellular
Ca2+ by EGTA
reduced the PGE2 induced
IL-6 secretion
Adebanjo et al., J Cell Biol 1998
(Bone Resorption) :
Additionally,
IL-6 ( 5 pg/l to 10 microg/l )
inhibited cytosolic
Ca2+ signals triggered by high Ca2+ or Ni2+ ... Thus, while high
Ca2+ enhances
IL-6 secretion, the released IL-6 attenuates Ca2+ sensing and reverses inhibition of resorption by Ca2+