◀ Back to IRF1
CIITA — IRF1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
IRF1
→
CIITA
(transcriptional regulation, unknown)
Dong et al., J Immunol 1999*, Xi et al., Mol Immunol 2003*, Piskurich et al., Mol Cell Biol 1999*
Evidence: DNABINDING, PROMACTIVITY, REG
-
FastForward regulation:
IRF1
→
CIITA
(transcriptional regulation, increase)
Piskurich et al., Mol Cell Biol 1999*
Evidence: DNABINDING, PROMACTIVITY, REG
-
FastForward regulation:
IRF1
→
CIITA
(transcriptional regulation, increase)
Dong et al., J Immunol 1999*
Evidence: DNABINDING, PROMACTIVITY, REG
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Salvati et al., Pediatr Res 2003*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Rahat et al., Int Immunol 2001*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Rohn et al., J Immunol 1999*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Morris et al., Mol Cell Biol 2002*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Zhao et al., Mol Immunol 2007*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Tooze et al., J Immunol 2006*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Piskurich et al., Mol Immunol 2006*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Xi et al., Oncogene 1999*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Ni et al., Proc Natl Acad Sci U S A 2005
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Ni et al., Nat Immunol 2008*
-
IRef Innatedb Interaction:
IRF1
—
CIITA
(unknown, -)
Xi et al., Mol Immunol 2003*
-
IRef Innatedb Interaction:
Complex of CIITA-IRF1-IRF2
(unknown, -)
Xi et al., Oncogene 1999*
Text-mined interactions from Literome
Xi et al., Oncogene 1999
(Pancreatic Neoplasms) :
In addition, we found that
IRF-1 and IRF-2 synergistically
activate the
CIITA Type IV promoter
Xi et al., Oncogene 2001
:
In addition to IRF-1,
IRF-2 , another member of the IRF family, also
activates the human
CIITA type IV promoter, and IRF-2 cooperates with IRF-1 to activate the promoter in transient transfection assays
Rahat et al., Int Immunol 2001
:
Thus we propose that
IRF-1 binding
mediates the synergistic induction of HLA-DRalpha and
CIITA in thyroid cells
Xi et al., Mol Immunol 2003
:
The IFN-gamma activation of the
CIITA type IV promoter is
mediated by STAT1 and
IRF-1 , which bind to the GAS and IRF-E of the promoter, respectively ... Deletion analysis of functional domains of IRF-2 revealed that a previously described latent activation domain of IRF-2 was essential for IRF-2 transactivation and participated in cooperative
activation of the
CIITA promoter by
IRF-1 and IRF-2
Giroux et al., J Immunol 2003
:
Collectively, our data suggest a novel regulatory mechanism for IFN-gamma induced MHC-II expression, whereby PKC
regulates CIITA expression by selectively modulating the transcriptional activity of
IRF-1
Hobart et al., J Immunol 1997
(Inflammation) :
Impaired class II induction by rIFN-gamma in IRF-1 KO mice probably reflects the
role of
IRF-1 in regulating
class II transactivator (CIITA) expression : rIFN-gamma induced CIITA mRNA less in kidneys of IRF-1 KO mice than in WT mice ... Treatment of WT mice with cycloheximide plus rIFN-gamma superinduced
IRF-1 mRNA expression, but partially
inhibited CIITA mRNA expression, indicating that IRF-1 mRNA induction is not dependent on new protein synthesis, unlike CIITA
Sims et al., Transplantation 1997
(Kidney Diseases) :
CIITA induction by injury is largely IFN-gamma independent but
requires IRF-1