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DTX1 — NOTCH4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yamamoto et al., J Biol Chem 2001
:
We show that
Deltex-1 (DTX1) , a mammalian homolog of Drosophila Deltex,
mediates a
Notch signal to block differentiation of neural progenitor cells
Endo et al., Dev Growth Differ 2003
:
Deltex/Dtx mediates
NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development
Höflinger et al., J Immunol 2004
:
At the same time,
Notch signaling rapidly
induces cell surface expression of the c-Kit receptor and transcription of the target genes
Deltex1 and pre-Talpha concomitant with the activation of TCR Vbeta germline transcription and the regulatory genes GATA3 and Tcf1
Hu et al., Dev Neurosci 2006
:
Remarkably, all these F3 and
NB-3/Notch cascade related events
required Deltex1 as the intermediate element
Lehar et al., Mol Cell Biol 2006
:
Deltex1 is highly
induced by
Notch signaling in thymocytes, and overexpression of Deltex1 in T-cell progenitors can block Notch signals, suggesting that Deltex1 may play an important role in regulating Notch signals during T-cell development
Jundt et al., Leukemia 2008
(Hodgkin Disease) :
We provide evidence that absence of the Notch inhibitor
Deltex1 contributes to deregulated
Notch activity in Hodgkin and Reed-Sternberg cells
Van de Walle et al., Blood 2009
:
High
Notch activity
increases DTX1 , NRARP, and RUNX3 expression, genes that are down-regulated during alphabeta-lineage differentiation
Zhang et al., Oncogene 2010
(Bone Neoplasms...) :
Regulation of
NOTCH signaling by reciprocal inhibition of HES1 and
Deltex 1 and its role in osteosarcoma invasiveness ... The inhibitory
effect of endogenous
Deltex1 on
NOTCH signaling is mediated through binding with the intracellular domain of NOTCH and ubiquitination and degradation of NOTCH receptors
Huber et al., PloS one 2013
:
Over-expression of
DTX1 increased cell migration and invasion correlating to ERK activation, miR-21 levels and endogenous
Notch levels