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NFKB1 — SPHK1

Text-mined interactions from Literome

Billich et al., Cell Signal 2005 : Suppression of SPHK1 activation led to reduction of cytokine induced IkappaBalpha phosphorylation and consequently diminished NFkappaB activity due to reduced nuclear translocation of RelA ( p65 ), explaining the dependence of inflammatory mediator production on SPHK1 activation
Gurgui et al., Cell Signal 2010 : Although our experimental data clearly show the mediatory role of sphingosine kinase ( SK ) -derived S1P in the TNF-alpha and the LPS induced activation of NF-kB , exogenously added S1P failed to trigger this transcription factor