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CEBPB — NFKB1

Pathways - manually collected, often from reviews:

• KEGG Tuberculosis: NFKB1/RELA → CEBPB/CEBPG (gene expression, expression)
• Reactome Reaction: CEBPB → NFKB1 (indirect_complex) Hartupee et al., J Biol Chem 2008, Kuilman et al., Cell 2008, Orjalo et al., Proc Natl Acad Sci U S A 2009, Lee et al., Mol Cell Biol 2010, Lee et al., J Biol Chem 2010, Libermann et al., Mol Cell Biol 1990, Shimizu et al., Mol Cell Biol 1990, Matsusaka et al., Proc Natl Acad Sci U S A 1993, Kunsch et al., Mol Cell Biol 1993, Stein et al., Mol Cell Biol 1993, Jimi et al., J Biol Chem 1996
• Reactome Reaction: CEBPB → NFKB1 (reaction) Hartupee et al., J Biol Chem 2008, Kuilman et al., Cell 2008, Orjalo et al., Proc Natl Acad Sci U S A 2009, Lee et al., Mol Cell Biol 2010, Lee et al., J Biol Chem 2010, Libermann et al., Mol Cell Biol 1990, Shimizu et al., Mol Cell Biol 1990, Matsusaka et al., Proc Natl Acad Sci U S A 1993, Kunsch et al., Mol Cell Biol 1993, Stein et al., Mol Cell Biol 1993, Jimi et al., J Biol Chem 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CEBPB — NFKB1 (direct interaction, pull down) LeClair et al., Proc Natl Acad Sci U S A 1992*
• IRef Hprd Interaction: CEBPB — NFKB1 (in vivo) LeClair et al., Proc Natl Acad Sci U S A 1992*
• IRef Hprd Interaction: CEBPB — NFKB1 (in vitro) LeClair et al., Proc Natl Acad Sci U S A 1992*
• IRef Innatedb Interaction: NFKB1 — CEBPB (unknown, -) O'Hara et al., J Biol Chem 2010*
• IRef Ophid Interaction: NFKB1 — CEBPB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: NFKB1 — CEBPB (aggregation, confirmational text mining) LeClair et al., Proc Natl Acad Sci U S A 1992*

Text-mined interactions from Literome

Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Employing gel shift assays, NF-kappaB, C/EBPbeta , and c-Jun were constitutively activated in RA FLS, but only NF-kappaB and c-Jun activity increased after IL-1beta
Jana et al., J Neurochem 2002 : Taken together, these studies suggest that activation of both NF-kappaB and C/EBPbeta is important for strong induction of TNF-alpha and that CD40 ligation regulates the expression of TNF-alpha by modulating the activation of only NF-kappaB but not that of C/EBPbeta
Webb et al., J Dent Res 2002 (Osteosarcoma) : Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that NFkappaB activity was enhanced and that constitutive C/EBPbeta was inhibited by TNF-alpha, with both effects being p38 MAPK dependent
Hoshino et al., J Exp Med 2002 (HIV Infections...) : This is associated with loss of an inhibitory CCAAT enhancer binding protein beta ( C/EBPbeta ) transcription factor and activation of nuclear factor (NF)-kappaB
Nakata et al., Kekkaku 2002 (HIV Infections...) : Reduction of expression of an inhibitory C/EBP beta transcription factor and activation of NF-kappa B are observed at the site of inflammation
Kravchenko et al., J Biol Chem 2003 (Inflammation) : This link includes an NF-kappaB dependent regulation of C/EBPbeta and C/EBPdelta gene transcription and IKKi mediated activation of C/EBP
Zhu et al., J Biol Chem 2003 : Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid independent activation of NF-kappaB
Radoja et al., Mol Cell Biol 2004 (Epidermolysis Bullosa) : We found that C/EBP-beta and AP-1 induced, while retinoic acid, glucocorticoid receptors, and NF-kappaB suppressed , the K15 promoter, along with other keratin gene promoters
Auch et al., FEBS Lett 2004 : This study delineates a novel role of dsRNA in inducing the expression of iNOS through dsRNA activated protein kinase ( PKR ) -mediated activation of NF-kappaB and p38 mediated activation of C/EBPbeta in human astroglia that may participate in virus induced neurological abnormalities
Kim et al., Biochem Biophys Res Commun 2005 : Taken together, these results suggest that 8HQ acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPbeta DNA binding activity and NF-kappaB activation
Zwergal et al., J Immunol 2006 : C/EBP beta blocks p65 phosphorylation and thereby NF-kappa B-mediated transcription in TNF-tolerant cells
Patel et al., J Biol Chem 2007 : These results, confirmed in primary human hepatocytes and CASMC, demonstrate for the first time that IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2 dependent NF-kappaB and C/EBPbeta activation and suggest that IL-17 may mediate chronic inflammation, atherosclerosis, and thrombosis
Du et al., J Immunol 2009 : CsA and FK506, as well as other UPR inducers, caused up-regulation of C/EBP family members, especially C/EBPbeta and CHOP ( C/EBP homologous protein ), and overexpression of either C/EBPbeta or CHOP significantly attenuated TNF-alpha triggered NF-kappaB activation
Cappello et al., Cell Signal 2009 : This was accompanied by elevated nuclear p65 and NF-kappaB activity in the presence of C/EBPbeta
Yu et al., J Biol Chem 2009 (Inflammation...) : In addition, IDR-1 induced p38 MAPK activity in a p62 dependent manner and increased CCAAT-enhancer binding protein beta activity, whereas NF-kappaB activity was unaffected
Hayakawa et al., J Am Soc Nephrol 2010 : Overexpression of C/EBPbeta markedly suppressed TNF-alpha induced activation of NF-kappaB , independent of its transacting potential