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EGF — IL1A

Text-mined interactions from Literome

Takahashi et al., J Pharmacol Exp Ther 1999 (Stomach Ulcer) : We investigated the role of endogenous interleukin (IL)-1 in the mRNA expression of cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS), cytokine induced neutrophil chemoattractant ( CINC ) -1, epidermal growth factor (EGF) , basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and transforming growth factor (TGF)-beta1 in acetic acid induced gastric ulcers in rats
Tan et al., Sheng Li Xue Bao 2002 : The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL-1 and IL-8 from unstimulated and O3-stressed BECs, VIP also decreased the secretion of IL-5 from O3-stressed BECs ; EGF promoted secretion of IL-1 and IL-8 from unstimulated BECs, but decreased the secretion of ILs from O3-stressed BECs ; ET-1 and CGRP enhanced the secretion of IL-1, IL-5, and IL-8 from unstimlated BECs, CGRP also increased the secretion of ILs from O3-stressed BECs
Deaciuc et al., Alcohol Clin Exp Res 2002 (Liver Diseases, Alcoholic) : EGF did not affect liver mRNA expression of TNF-alpha, IL-1beta , IL-6, and IL-10, which suggested that these cytokines were not involved in EGF protective effect
Le et al., J Exp Med 1991 : Regulation of cytokine production in the human thymus : epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level ... Neither EGF nor TGF-alpha increased transcription rates of IL-1 alpha , IL-1 beta, and IL-6 genes, but rather both EGF and TGF-alpha increased cytokine mRNA stability
Ko et al., PloS one 2013 (Carcinoma, Squamous Cell) : The expression of cytokines, such as IL-1ß , and the activation of the epidermal growth factor receptor (EGFR) are crucial regulators in the process of carcinogenesis ... In our study, we found that the IL-1ß gene and protein expression were induced by EGF in squamous cell carcinoma ... To clarify the mechanism involved in EGF regulated IL-1ß expression, we examined the transcriptional activity and mRNA stability of IL-1ß in EGF treated cells ... We found that EGF induced the expression of IL-1ß and was mediated through transcriptional activation, but not through mRNA stability ... The involvement of Akt and NF-?B signaling pathways in the EGF induced IL-1ß gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-?B inhibitors, LY294002 and parthenolide, respectively ... The expression of dominant negative I?B also repressed the activation of NF-?B and inhibited EGF induced IL-1ß expression ... Furthermore, EGF increased the binding of NF-?B to the NF-?B binding site of the IL-1ß promoter through the activation of the Akt/NF-?B pathway, which resulted in activating IL-1ß promoter activity ... The expression and secretion of IL-1ß induced by EGF considerably reduced chemotherapeutic drug cisplatin induced cell death ... These results showed that EGF enhanced the expression of IL-1ß , which was mediated by the Akt/NF-?B pathway
Wise et al., Cell Tissue Res 1995 : Epidermal growth factor (EGF) enhanced the gene expression of interleukin-1 alpha in stellate reticulum cells in vitro, and this study suggests there is enhanced translation of interleukin-1 alpha messenger RNA in the stellate reticulum following EGF injection
Modéer et al., Cytokine 1993 : IL-1 alpha , IL-1 beta and TNF-alpha, but not EGF nor TGF-alpha, stimulated prostaglandin E2 ( PGE2 ) formation in the gingival fibroblasts
Jones et al., Acta Endocrinol (Copenh) 1993 (Adenoma...) : Interleukin-1 (IL-1) stimulated IL-6 release after a 24-h incubation period in five of the seven IL-6 secreting adenoma cultures and in all seven after 72 h. Tumour necrosis factor, interferon-gamma and epidermal growth factor did not significantly affect IL-6 secretion
Schluns et al., J Immunol 1997 : TGF-beta differentially modulates epidermal growth factor mediated increases in leukemia-inhibitory factor, IL-6, IL-1 alpha , and IL-1 beta in human thymic epithelial cells