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CD28 — CDC42

Pathways - manually collected, often from reviews:

• Reactome Reaction: CD28 → CDC42 (reaction) Han et al., Mol Cell Biol 1997*

Text-mined interactions from Literome

Salazar-Fontana et al., J Immunol 2003 : The signaling pathway coupling CD28 to cytoskeletal rearrangements required Src related kinase activity and promoted Vav phosphorylation and Cdc42 activation independently of the zeta-chain associated kinase ( ZAP-70 )
Müller et al., Traffic 2006 : Consistent with their inability to activate Cdc42 and Rac1 in response to the ligation of CD3/CD28 , T cells exposed to MV fail to acquire a morphology consistent with spreading and lamellopodia formation