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CCND2 — RB1

Pathways - manually collected, often from reviews:

• BioCarta cyclins and cell cycle regulation: RB/E2F-1 complex (E2F1-RB1) → CDK4/cyclin D2 complex (CDK4-CCND2) (modification, collaborate)
  
• BioCarta cyclins and cell cycle regulation: CDK4/cyclin D2 complex (CDK4-CCND2) → RB (RB1) (modification, activates)
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RB1 (protein-protein, inhibition)
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• WikiPathways Signaling Pathways in Glioblastoma: Complex of CCND1-CCND2-CDK4 → RB1 (mim-inhibition)
• WikiPathways Signaling Pathways in Glioblastoma: Complex of CCND1-CCND2-CDK6 → RB1 (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCND2 — RB1 (direct interaction, enzymatic study) Moorthamer et al., Biochem Biophys Res Commun 1999*
• IRef Biogrid Interaction: CCND2 — RB1 (direct interaction, enzymatic study) Sweeney et al., Oncogene 1997*
• IRef Biogrid Interaction: CCND2 — RB1 (direct interaction, enzymatic study) Jiang et al., Mol Cell 1998
• IRef Hprd Interaction: CCND2 — RB1 (in vivo) Tanguay et al., J Immunol 2001*, Kitagawa et al., EMBO J 1996*
• IRef Hprd Interaction: CCND2 — RB1 (in vitro) Tanguay et al., J Immunol 2001*, Kitagawa et al., EMBO J 1996*

Text-mined interactions from Literome

Busk et al., Exp Cell Res 2005 : At the molecular level, cyclin D2 activated CDK4/6 and lead to pRB phosphorylation and downregulation of the cell cycle inhibitors p21Waf1/Cip1 and p27Kip1
Guo et al., J Biol Chem 2009 : Cyclin A, cyclin D1, cyclin D2 , and Cdk4/6 expression was not affected by absent pRb expression