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SOS1 — SRC
Pathways - manually collected, often from reviews:
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
→
SHC (SHC1)
(modification, collaborate)
-
BioCarta erk1/erk2 mapk signaling pathway:
SRC
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta links between pyk2 and map kinases:
SOS-1 (SOS1)
→
PYK2/SRC complex (PTK2B-SRC)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
SOS-1 (SOS1)
→
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC complex (PTK2B-SRC)
→
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1)
→
GRB2
(modification, collaborate)
-
BioCarta calcium signaling by hbx of hepatitis b virus:
PYK2/SRC complex (PTK2B-SRC)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
None
→
FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN)
(modification, collaborate)
Furuhjelm et al., J Cell Sci 2003, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997
Evidence: mutant phenotype
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
RRAS/GDP complex (RRAS)
→
FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN)
(modification, collaborate)
Furuhjelm et al., J Cell Sci 2003, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997
Evidence: mutant phenotype
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
Evidence: physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
Evidence: physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN)
→
FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN)
(modification, collaborate)
Shen et al., FEBS Lett 2001, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1996, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997, Li et al., J Biol Chem 1997, Schlaepfer et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Shen et al., FEBS Lett 2001, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1996, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997, Li et al., J Biol Chem 1997, Schlaepfer et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Shen et al., FEBS Lett 2001, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1996, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997, Li et al., J Biol Chem 1997, Schlaepfer et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
SOS1
→
SRC
(reaction)
-
Reactome Reaction:
SOS1
→
SRC
(indirect_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Am J Physiol Cell Physiol 2007
(MAP Kinase Signaling System) :
ANG II induced a
Src dependent association between Shc and growth factor receptor bound protein 2 ( Grb2 ) and between Grb2 and
son of sevenless ( Sos ) , both of which were maximal at 15 min
Samoylenko et al., Carcinogenesis 2012
(Adenocarcinoma...) :
Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of
Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility