Tai et al., J Biol Chem 2005
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Tie2 and PECAM1 expression decreased > 80 % after siRNA treatment, and flow stimulated phosphorylation of ERK1/2 , Akt, and endothelial nitric oxide synthase was significantly inhibited by Tie2 and PECAM1 siRNA
Yeh et al., Biochemistry 2008
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Activation of ERK1/2 by bradykinin in HUVEC is enhanced when PECAM-1 expression is inhibited by transfection of small interference RNA against PECAM-1