Gene interactions and pathways from curated databases and text-mining

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IL6 — IL6R

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Naruishi et al., J Periodontal Res 1999 (Chronic Disease...) : Role of soluble interleukin-6 receptor in inflamed gingiva for binding of interleukin-6 to gingival fibroblasts
Ling et al., Crit Care Med 2002 : In endotoxin treated rats, there was significant inhibition of interleukin-6 activation of janus kinase-1, gp 130, the interleukin-6 receptor , STAT1, and STAT3
Zohlnhöfer et al., FEBS Lett 1992 (Carcinoma, Hepatocellular) : We studied the role of gp80 in binding, internalization and down-regulation of the hepatic IL6-receptor (IL6R) by its ligand in human hepatoma cells ( HepG2 ) ... Comparison of transfected HepG2 cells overexpressing gp80 with parental cells indicate that gp80 is responsible for low affinity binding ( Kd = 500 pM ) of IL6
Mackiewicz et al., FEBS Lett 1992 (Carcinoma, Hepatocellular...) : Stable transfection of IL-6-cDNA into HepG2 cells ( HepG2-IL-6 ) resulting in constitutive secretion of 2 micrograms of IL-6 per 10 ( 6 ) cells in 24 h led to a down-regulation of surface bound gp80 and subsequent homologous desensitization of HepG2-IL-6 cells towards IL-6
Kovacs et al., Biomed Pharmacother 2003 (Multiple Myeloma) : How does interleukin-6 affect the membrane expressions of interleukin-6 receptor and gp130 and the proliferation of the human myeloma cell line OPM-2 ?
Zeng et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2005 (Osteoporosis) : Beginning from the 2nd week, the osteoclasts formation in Group B was higher than that in Group A ( P < 0.05 ), and IL-6 , IL-6R gene expression significantly increased in Group B ( P < 0.05 or P < 0.01 )
Dovio et al., Eur J Endocrinol 2006 (Bone Resorption...) : Soluble IL-6Ralpha ( sIL-6Ralpha ) enhances , while sgp130 inhibits IL-6 signalling
Kovacs et al., TheScientificWorldJournal 2006 (Lymphoma, B-Cell...) : In this study, we investigated the effects of IL-6, IL-6 receptor antagonist (IL-6RA) , and gp130 antagonist (gp130A) on the membrane expressions of IL-6R and gp130, on the viability, on the proliferation, on the DNA synthesis, and on the cell cycle phases in several multiple myeloma ( MM ) cell lines and B cell lymphoma cell lines
Ghazizadeh et al., J Invest Dermatol 2007 (Keloid) : Induction of IL-6 by IL-1beta peptide and stimulation by IL-6 peptide in NFs, or inhibition of IL-6 or IL-6R alpha in KFs cultures demonstrated a dose dependent increase or decrease in procollagen I synthesis, respectively
Rabe et al., Blood 2008 (Acute Disease...) : Here we developed a transgenic strategy based on the overexpression of the soluble form of gp130, which specifically blocks all IL6 responses mediated by the soluble IL6R but does not affect IL6 responses via the membrane bound IL6R
Suh et al., J Cell Physiol 2009 : IL-6 ( 10 ng/ml ) increased the level of IL-6Ralpha and glycoprotein (gp) 130 ( IL-6Rbeta ) protein expressions
Dela Cruz et al., J Biol Chem 2009 : Human IL-6 , but not vIL-6, requires IL-6Ralpha for binding to gp130
Buchholz et al., Neurogastroenterol Motil 2012 (Ileus...) : However, IL-6R blockade did not prevent endotoxin associated mortality nor did it alter circulating IL-6 levels
Stone et al., PloS one 2013 (Giant Lymph Node Hyperplasia) : These elevated interleukin-6 receptor levels may contribute to increased interleukin-6 activity through the trans signaling pathway
Egawa et al., Cytokine 1995 : Our data suggest that the human IL-6R alpha-subunit gp80 is sufficient to confer high- and low-affinity IL-6 binding to Xenopus laevis oocytes
Lasfar et al., Eur J Immunol 1994 (Multiple Myeloma) : These data indicate that, in myeloma cells, IL-6R are differentially regulated by IL-6 and IFN-alpha
Xi et al., Zhonghua Zhong Liu Za Zhi 1993 (Leukemia, Promyelocytic, Acute) : The effect of the recombinant IL6-PE40 on both the LT12-IL6R+ cells and the IL6R- parental cells ( LT12-IL6R- ) was studied by leukemic progenitor colony ( CFU-L ) formation and 3H-TdR incorporation assays
Rose-John et al., J Biol Chem 1993 : Retention of IL-6 in the ER led to the prevention of surface expression of the IL-6 receptor protein gp80 , making these cells unresponsive to IL-6
Suzuki et al., Eur J Immunol 1993 (Autoimmune Diseases...) : Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal
Cichy et al., Biochem Biophys Res Commun 1996 : Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts ... In this study the ability of soluble interleukin-6 receptor ( sIL-6R ) to stimulate interleukin-6 (IL-6) synthesis in human fibroblasts is described
Gatsios et al., Eur J Biochem 1996 : Interleukin-6 itself had no effect on synovial lining cells but a complex of interleukin-6 and the soluble interleukin-6 receptor induced activation of signal transducer and activator of transcription ( STAT ) factors in these cells and regulated TIMP-1 and TIMP-3 expression in a similar fashion as oncostatin M
Sun et al., Eur Cytokine Netw 1997 : All the IL-6RA inhibited wild-type IL-6
Feleder et al., Biol Signals Recept 1998 : IL-6ra also increased IL-6 levels measured in medium probably due to a decrease in the metabolization induced by the blockage of the receptors and the consequent accumulation of IL-6 in the media
Säily et al., Growth Factors 1998 (Leukemia, Myeloid, Acute) : Expression of interleukin-6 (IL-6) receptor gene in acute myeloblastic leukemia and response of leukemic cells to exogenous IL-6
Sawamura et al., J Immunol 1998 (Inflammation...) : Furthermore, preintroduction of some mutant genes delayed the erythema induced by postintroduction of the wild-type IL-6 gene, suggesting that the mutant forms of IL-6 prevent wild-type IL-6 from binding to IL-6Ralpha
van der Meijden et al., Cell Immunol 1998 (HIV Infections) : CD126 is responsible for IL-6 binding, and its expression determines which cells respond to this cytokine