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IL6 — TLR3

Text-mined interactions from Literome

Kurt-Jones et al., J Endotoxin Res 2004 : MEFs were highly responsive to TLR-ligand activation and secreted high levels of both IL-6 and MCP-1 in response to TLR ligands
Goral et al., J Immunol 2005 (Inflammation) : Furthermore, different TLR ligands stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Seki et al., Hepatology 2005 : However, TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways
Jorgenson et al., Hum Immunol 2005 : We established that stimulation of TLR3 positive cell lines and primary human endometrial epithelial cells with dsRNA leads to TLR3 dependent expression of interleukin (IL)-6 , IL-8, interferon ( IFN ) -inducible protein 10, RANTES, and IFN-beta
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6 , nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Zhang et al., EMBO J 2006 : We found that the serine phosphorylation was crucial for TLR induced interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway
Kuwata et al., Immunity 2006 (Colitis...) : IkappaBNS-deficient macrophages and dendritic cells show increased TLR mediated expression of genes such as IL-6 and IL-12p40, which are induced late after TLR stimulation
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Hayashi et al., J Gen Virol 2006 : Treatment of HCRFs transfected with HSV DNA with the TLR-9-inhibitory oligomer iODN, anti-TLR-3 antibody or phosphatidylinositol 3-kinase inhibitor indicated that IL-6 release from HCRFs was mediated by TLR-3 and -9 gene expression
Ramakers et al., Cytokine 2006 : Finally, CGS21680 potentiated TLR5 mediated IL-6 production compared to TLR1-2 stimulation, and potentiated TLR3- and TLR5 mediated IL-10 production compared to TLR1-2 mediated stimulation
Broad et al., Immunology 2007 : In this study we have shown that, whilst NF-kappaB activation and production of TNF-alpha and interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4, -5, -7 or -9, was reduced by prior stimulation with TLR4, -5, -7 or -9 ligands, the primary stimulation of TLR3 , which does not use the MyD88 pathway, did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation
Boyd et al., Cardiovasc Res 2006 (Myocarditis) : Ligand activation of TLR2, TLR4 and TLR5, but not TLR3, TLR7 or TLR9, resulted in cardiomyocyte expression of the inflammatory cytokine IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1
Flacher et al., J Immunol 2006 : TLR2 and TLR3 ligands increase IL-6 and IL-8 production, while dsRNA alone stimulates TNF-alpha release
Yu et al., Int J Cancer 2007 (Melanoma, Experimental) : However, CX3CR1-deficient NK cells exhibited a tumorigenic cytokine production profile with defective IFN-gamma expression and enhanced IL-6 production in response to TLR3 activation with polyIC
Shu et al., Clin Exp Immunol 2007 : natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-12 p40 in response to Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Batra et al., Am J Pathol 2007 : In WT preadipocytes the TLR responsiveness increased during maturation to adipocytes ; however, stimulation of ob/ob and db/db cells resulted in a 10- to 20-fold higher interleukin-6 production
Jack et al., J Neuropathol Exp Neurol 2007 : In vitro, ligation of TLR3 significantly increased major histocompatibility complex and costimulatory molecule expression on adult microglia and induced high levels of interferon-alpha, interleukin-12p40 , and interleukin-23
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6 , IL-10, IL-12 and IFN-gamma by B cells
Villacres et al., J Viral Hepat 2008 (Hepatitis C, Chronic) : Interleukin (IL)-6 in response to TLR3 and TLR4 ligands such as polyinosinic-polycytidylic acid and lipopolysaccharide was significantly compromised in HCV infected women
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha, but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Wilson et al., J Virol 2008 : Furthermore, NS1 expression also inhibited TLR3 dependent production of interleukin-6 and the establishment of an antiviral state
Castillo et al., Nanomedicine (Lond) 2008 : Ag @ tiopronin nanoparticles were not proinflammatory agents, but remarkably they specifically impaired the IL-6 secretion mediated by TLR2, TLR2/6 , TLR3 or TLR9 stimulation in co-treatment experiments
Pruett et al., J Immunotoxicol 2006 : Greater than additive suppression of TLR3 induced IL-6 responses by administration of dieldrin and atrazine
Ospelt et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : Among the expressed TLRs, TLR-3 and TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C ) led to the most pronounced increase in IL-6 , MMP-3, and MMP-13
Matsushita et al., Nature 2009 (Anemia...) : Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF, in response to TLR ligands
Jiang et al., Invest Ophthalmol Vis Sci 2009 (Autoimmune Diseases...) : TLR3 ligation increased the expression of MHC and costimulatory molecules and induced the production of IL-6 , IL-12, and IL-23 by RACs
Kenny et al., J Immunol 2009 : MyD88 was vital for all TLR2 and TLR4 responses and, similar to Mal, was also inhibitory for TLR3 dependent IL-6 and JNK induction
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Lanz et al., Stem Cells Dev 2010 (Encephalomyelitis, Autoimmune, Experimental) : This failure to catabolize trp is not due to defective TLR signaling as demonstrated by induction of interleukin 6 (IL-6) by TLR activation
Frazier et al., J Immunol 2009 (Escherichia coli Infections...) : MAPKs are crucial for TNF-alpha and IL-6 production by innate immune cells in response to TLR ligands
Suzuki et al., J Dent Res 2009 (Gingival Overgrowth) : In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses
McCartney et al., J Exp Med 2009 : MDA5 and TLR3 activated NK cells indirectly through accessory cells and induced the distinct stimulatory cytokines interferon-alpha and interleukin-12 , respectively
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma, tumor necrosis factor-alpha and IL-6 , which are known to promote DC maturation
Amu et al., Scand J Immunol 2010 : We found that CD25 ( + ) B cells secreted higher levels of IL-6 , IL-10 and INFgamma in response to different TLR-agonists , and were better at presenting alloantigen to CD4 ( + ) T cells
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Hunter et al., TheScientificWorldJournal 2010 (Peritonitis) : Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands
Jones et al., J Immunol 2010 : We compared the ability of progesterone to modulate murine bone marrow derived DC cytokine production ( IL-6 and IL-12 ) and costimulatory molecule expression ( CD40, CD80, and CD86 ) induced by either TLR3 or TLR4 ligation and determined whether activity was via the progesterone receptor (PR) or glucocorticoid receptor ( GR ) by comparative studies with the PR-specific agonist norgestrel and the GR agonist dexamethasone
Foldi et al., J Immunol 2010 : Jagged1 induction was augmented by IFN-?, was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways, and elevated Jagged1 expression augmented TLR induced IL-6 production
Chávez-Sánchez et al., Lipids in health and disease 2010 : The activation of CD14, TLR4 , and TLR2 by mmLDL induces IL-1ß, IL-6 , and IL-10 secretion in human monocytes and macrophages
Lavoie et al., J Infect Dis 2010 (Infant, Premature, Diseases...) : Preterm neonates had globally attenuated TLR stimulated interleukin (IL)-6 , interferon-a, and, to a lesser extent, tumor necrosis factor-a responses but demonstrated relative preservation of anti-inflammatory IL-10 responses in monocytes and dendritic cell subtypes
Agarwal et al., Arthritis Res Ther 2011 (Fibrosis...) : The ability of IFNa2 to regulate TLR induced interleukin (IL)-6 and CC chemokine ligand 2 production was also assessed ... IFNa2 increased TLR3 expression on human dermal fibroblasts, which resulted in enhanced TLR3 induced IL-6 production
Li et al., Glia 2011 : Nonselective and COX2-selective inhibitors blocked TLR3 induction of TNFa and IL-6
El-Hage et al., Immunol Invest 2011 : TLR3 and TLR4 stimulation increased the secretion of TNF-a, IL-6 , and RANTES/CCL5, while activation of TLR2 caused a significant increase in nitric oxide levels
Vaquero et al., Hepatology 2011 : CONCLUSION : TLR-4 signaling contributes to IL-6 activation after PH, but the Tlr4 independent component appears sufficient for ensuring intact signaling downstream of IL-6
Tang et al., Contrib Nephrol 2011 (Diabetic Nephropathies...) : In human DN biopsies and PTEC, TLR4is upregulated and plays a permissive role in HG-induced IL-6 and CCL-2 overexpression and monocyte transmigration
Séité et al., J Autoimmun 2011 (Autoimmune Diseases) : As a result, IVIg suppresses TLR induced production of the proinflammatory IL-6 , but not that of the anti-inflammatory IL-10
Chung et al., J Viral Hepat 2011 (Hepatitis B...) : We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with TLR ligands results in impaired IL-6 production by peripheral blood monocytes from HCV infected patients
Farrar et al., FASEB J 2012 (Disease Models, Animal...) : Activation of TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as IL-6 and TNF-a
Panda et al., J Reprod Immunol 2012 (Pre-Eclampsia) : The expression of TLR induced production of TNF-a, IFN-a, IL-6 , and IL-12 were measured by multicolor flow cytometry
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Siggs et al., Blood 2012 : Neither the missense nor the null allele affected TLR induced secretion of IL-6
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Zamora et al., Cytokine 2012 : Even though TLR-activation induced TNFa, IL-10 and IL-6 production, only recombinant TNFa was able to downregulate CD36
Kim et al., Microb Pathog 2013 : In addition, TLR4 was required for the optimal production of IL-6 , TNF-a, and IL-12 in BMDCs in response to A. baumannii
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2, TLR3 , TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6) , and Interleukin-8 (IL-8) )
Karrich et al., Blood 2013 : Although IL-21 did not affect TLR induced type I IFNs, IL-6 , and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Howell et al., Am J Transplant 2013 (Disease Progression...) : PBMCs from HCV rapid-fibrosers produced less IFNa with TLR7/8 stimulation ( p = 0.039 ), less IL-6 at baseline ( p = 0.027 ) and with TLR3 stimulation ( p = 0.008 ) and had lower TLR3 mediated monocyte IL-6 production ( p = 0.028 ) compared with HCV slow fibrosers
Giacomini et al., Eur J Immunol 2013 (Multiple Sclerosis, Relapsing-Remitting) : Furthermore, in MS-derived PBMCs, TLR7 mediated production of IL-6 and the ex vivo expression of B-cell activating factor of the TNF family, two crucial cytokines for B-cell differentiation and survival, were induced by IFN-ß
Gbédandé et al., Infect Immun 2013 (Malaria, Falciparum...) : In multivariate analyses, maternal P. falciparum infections at delivery were associated with significantly higher TLR3 mediated IL-6 and IL-10 responses in the first 3 months of life ( P < 0.05 ) and with significantly higher TLR3-, TLR7/8-, and TLR9 mediated TNF-a responses between 6 and 12 months of age ( P < 0.05 )
Liu et al., J Neurosci 2013 : In cultured neurons, TLR7 activation induced IL-6 and TNF-a expression through Myd88