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GRB2 — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hermanns et al., J Biol Chem 2000
:
In the present study, we demonstrate that oncostatin M (OSM), but not
IL-6 or leukemia inhibitory factor,
induces tyrosine phosphorylation of the Shc isoforms p52 and p66 and their association with
Grb2
Lee et al., Phytother Res 2013
(Inflammation) :
GRb1 significantly
reduced the upregulation of tumor necrosis factor-a,
interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection
Berger et al., Blood 1997
(Multiple Myeloma) :
Further analysis indicated that treatment with IFN-beta disrupted
IL-6 induced binding of PTP1D/Syp to gp130 and the adaptor protein
Grb2 ; IFN-beta pretreatment also interfered with IL-6 induced interaction of Shc with Grb2 and a 145-kD tyrosine phosphorylated protein
Ogata et al., Clin Cancer Res 1997
(Multiple Myeloma) :
gp130 phosphorylation, gp130-to-PTP1D binding, PTP1D phosphorylation, and
PTP1D-to-Grb2 binding are also
induced by
IL-6 in all IL-6 independent MM cell lines studied ... However,
Grb2 is not associated with Sos1, and neither Grb2-to-Sos1 binding nor Sos1 phosphorylation is
triggered by
IL-6 in OCI-My5 MM cells ... On the other hand,
Grb2 and Sos1 are associated constitutively in U266 and RPMI8226 MM cells, but phosphorylation of Sos1 is not
induced by
IL-6