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IL8 — RAC1

Text-mined interactions from Literome

Lokuta et al., Proc Natl Acad Sci U S A 2003 : Further, both calpain inhibition and stimulation with IL-8 and formyl-Met-Leu-Phe ( fMLP ) induced an increase in Cdc42 and Rac activation
Montaner et al., Blood 2004 (Sarcoma, Kaposi) : Inhibition of Rac1 blocked vGPCR induced transcription and secretion of KS cytokines, including interleukin-6 (IL-6), IL-8 , and growth regulated oncogene alpha ( GROalpha ), in vitro and reduced vGPCR tumorigenesis in vivo
Fuhler et al., J Leukoc Biol 2005 (Myelodysplastic Syndromes) : We then investigated IL-8 induced activation of the small GTPase Rac implicated in ERK1/2 dependent migration and found that it was less efficient in neutrophils from MDS patients compared with healthy donors
Schmeck et al., Biochem Pharmacol 2006 : Activation of RhoA, Rac1 and Cdc42 ( CNF1 ), but not of RhoA alone ( CNF ( Y ) ), enhanced Listeria dependent IL-8 release significantly
Lin et al., J Biol Chem 2011 : In this study, we further investigated the roles of Rac1 , phosphoinositide 3-kinase (PI3K), and Akt in thrombin induced NF-?B activation and IL-8/CXCL8 expression