Gene interactions and pathways from curated databases and text-mining

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CDH1 — MMP2

Text-mined interactions from Literome

Mei et al., Carcinogenesis 2002 : The sum effect of MMP inhibitors demonstrated that NO-induced activation of MMP may cause the degradation of E-cadherin and the subsequent dissociation of beta-catenin, thereby contributing to the cytosolic accumulation of beta-catenin and nuclear formation of beta-catenin/LEF-1 complex
Nawrocki-Raby et al., Am J Pathol 2003 (Bronchial Neoplasms...) : E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells
Wang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2004 (Lymphatic Metastasis...) : In the group of nasopharyngeal carcinoma with distant metastasis, the expression of E-cadherin and nm23H1 also increased and the expression of CD44H, MMP-3 and VEGF all increased
Liu et al., Biochem Biophys Res Commun 2006 : Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and -9
Jing et al., Dis Esophagus 2013 (Esophageal Neoplasms...) : Small interfering RNA could block HIF-1 alpha effectively under hypoxia, then enhanced E-cadherin expression and inhibited MMP-2 expression, respectively
Zhao et al., Cancer Lett 2013 (Neovascularization, Pathologic...) : EA also reversed epithelial to mesenchymal transition by up-regulating E-cadherin and inhibiting the expression of Snail, MMP-2 and MMP-9
Miao et al., Med Oncol 2013 : Enhanced DDR1 expression mediated by collagen I could activate MMP-2, N-cadherin and vimentin expression, but reduce E-cadherin expression ; however, inhibition of DDR1 expression could suppress MMP-2 , N-cadherin and vimentin expression and induce E-cadherin activation