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CASP14 — SYK
Text-mined interactions from Literome
Tohyama et al., Curr Pharm Des 2004
(Fanconi Anemia...) :
Syk might
inhibit the activation of
caspase-9 through Akt thereby protecting cells from oxidative stress induced apoptosis
Saïd-Sadier et al., PloS one 2010
:
Thus, our data demonstrate that the innate immune response against A. fumigatus infection involves a two step activation process, with a first signal promoting expression and synthesis of pro-IL-1beta ; and a second signal, involving
Syk induced activation of the NLRP3 inflammasome and
caspase-1 , allowing processing and secretion of the mature cytokine
Abdul-Sater et al., Microbes Infect 2010
:
Atypically for a bacterial infection,
caspase-1 activation during chlamydial infection also
involves partially the
spleen tyrosine kinase (Syk) , which is usually associated with a pathogen recognition receptor for fungal pathogens
Lee et al., Immunol Cell Biol 2012
(Mycobacterium Infections, Nontuberculous) :
Dectin-1 dependent
Syk signaling, but not that of MyD88,
led to the activation of
caspase-1 and secretion of IL-1ß through the activation of an NLRP3/apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) inflammasome
Lu et al., PLoS Pathog 2012
(Inflammation...) :
Blocking
Syk activation by kinase inhibitors or RNAi
reduced Syk phosphorylation, lysosomal destabilization, ROS production, and
caspase-1 activation in Ceacam1?/? neutrophils