Liao et al., Endocrinology 2006
(Body Weight...) :
In WT mice, the GH antagonist pegvisomant (Peg) suppressed the transcription of endogenous IGF-I and acid-labile subunit (ALS) genes with no effect on IGF binding protein 3 (IGFBP-3) mRNA
Miller et al., Neurology 2009
(Amyotrophic Lateral Sclerosis) :
More studies are needed to examine the best tests of respiratory function in ALS, as well as the optimal time for starting PEG, the impact of PEG on quality of life and survival, and the effect of vitamins and supplements on ALS