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CDKN1A — SP3

Text-mined interactions from Literome

Xiao et al., J Cell Biochem 1999 : Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells ... These findings provide physical and functional evidence which strongly indicated that both Sp1 and Sp3 are responsible for TSA induced transactivation of the murine p21WAF1 promoter in NIH3T3 cells
Sowa et al., Cancer Res 1999 : Sp3 , but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor
Gartel et al., Oncogene 2000 (Adenocarcinoma...) : Sp1 and Sp3 activate p21 ( WAF1/CIP1 ) gene transcription in the Caco-2 colon adenocarcinoma cell line
Santini et al., Proc Natl Acad Sci U S A 2001 : We find that the endogenous NFAT-1 and -2 transcription factors, major downstream targets of calcineurin, associate with Sp1 in keratinocytes in a calcineurin dependent manner, and calcineurin up-regulates Sp1/Sp3 dependent transcription and p21 promoter activity in synergism with NFAT1/2
Hong et al., Carcinogenesis 2002 (Breast Neoplasms) : Thus, our observations have uncovered an antiproliferative pathway for DIM that implicates Sp1/Sp3 induced expression of p21 as a target for cell cycle control in human breast cancer cells
Koutsodontis et al., Biochemistry 2002 : Sp1, but not Sp3 , mediated the transactivation of the p21 promoter by the TGFbeta signaling mediator Smad3 and Smad4 proteins whereas none of the individual mutations in elements 1-6 affected the transactivation of the p21 promoter by Smad proteins in HepG2 cells
Sakaguchi et al., J Cell Biol 2003 (Calcium Signaling) : The resulting free Sp1/3 transcriptionally activated p21CIP1/WAF1 , a representative negative regulator of cell growth
Sakaguchi et al., Proc Natl Acad Sci U S A 2005 : On exposure of NHK cells to either agent, S100C/A11 is transferred to nuclei, where it induces p21WAF1/CIP1 through activation of Sp1/Sp3
Lee et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : Activation of p21 promoter constructs by DIM-C-pPhOCH3 required the GC-rich proximal region of the promoter, and results of RNA interference studies showed that Nur77 dependent activation of the p21 promoter involved interactions with Sp1 and Sp4 but not Sp3
Valin et al., Mol Cell Biol 2013 : Here we report that the transcription factor Sp3 inhibits basal p21 ( CIP1 ) gene expression by promoter bound RNA PolII
Valin et al., Cell cycle (Georgetown, Tex.) 2013 : In contrast, Sp3 promoted binding of the protein phosphatase PP1 to the p21 ( CIP1 ) promoter, suggesting that Sp3 dependent regulation of the local balance between kinase and phosphatase activities may contribute to gene expression
Prowse et al., J Biol Chem 1997 : Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation ... Expression studies established that both Sp1 and Sp3 activate the p21 promoter, but showed that only Sp3 overexpression enhances promoter inducibility during differentiation ... These findings show that both Sp1 and Sp3 can contribute to the basal activity of the p21 promoter, and establish Sp3 as a specific transcription factor involved in the induction of p21 promoter during keratinocyte differentiation
Adnane et al., Mol Cell Biol 1998 (Pancreatic Neoplasms) : These results suggest that GGTI-298 mediated upregulation of p21 ( WAF1/CIP1 ) involves both an increase in the amount of DNA bound Sp1-Sp3 and enhancement of Sp1 transcriptional activity