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HRAS — IRS1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HRAS → IRS1 (increases, IRS1 Activity)
  Evidence: phosphorylated IRS1 also stimulates the Ras-Raf-MEK-ERK pathway, a MAPK pathway
• OpenBEL Selventa BEL large corpus: HRAS → IRS1 (increases, IRS1 Activity)
  Evidence: IGF1 binding activates the IGF1 receptor (IGFR), a receptor tyrosine kinase. The IGFR subsequently recruits the insulin receptor substrate (IRS1), which results in the activation of two signaling pathways: the RasRaf MEK ERK pathway and the PI3K Akt pathway
• NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GTP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GDP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• Reactome Reaction: IRS1 → HRAS (reaction)
• WikiPathways Insulin Signaling: SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 → RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 (activation)
  

Text-mined interactions from Literome

Taha et al., J Biol Chem 1995 : Insulin binding results in rapid phosphorylation of insulin receptor substrate-1 to activate p21ras and mitogen activated protein kinase
Sasaoka et al., J Biol Chem 1994 : We investigated the relative role of IRS-1 and She in insulin activation of guanine nucleotide releasing factor ( GNRF ) and p21ras-GTP formation
Mèndez et al., Mol Cell Biol 1996 : Stimulation of general protein synthesis does not involve activation by IRS-1 of GRB-2-SOS-p21ras or SH-PTP2, since IRS-1 variants lacking the SH2 binding Tyr residues for these proteins are fully active