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CXCL9 — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCL9 → IFNG (increases)
  Evidence: It is of interest that IFNG stimulates dendritic cells to produce IP-10 and Mig.
• OpenBEL Selventa BEL large corpus: CXCL9 → IFNG (increases) Mach et al., J Clin Invest 1999*
  Evidence: Western blot analysis for IP-10, Mig, and I-TAC extended Northern blot results to detection of all 3 proteins after IFN-g stimulation in ECs (Figure 7b).
• OpenBEL Selventa BEL large corpus: CXCL9 → IFNG (increases)
  Evidence: the CXC chemokines Mig and interferon-? inducible protein 10 can be expressed and bound by endothelium stimulated with interferon-? and tumor necrosis factor (TNF) ?, and can induce the firm adhesion of T lymphocyte in shear flow via CXCR3.
• OpenBEL Selventa BEL large corpus: CXCL9 → IFNG (increases, IFNG Translocation) Tudhope et al., J Immunol 2007*
  Evidence: human primary airway epithelial cells (13, 14) and human airway smooth muscle cells (15) express these ligands following stimulation with IFN-.

Text-mined interactions from Literome

Sauty et al., J Immunol 1999 : We found that IFN-gamma , but not TNF-alpha or IL-1 beta, strongly induced IP-10, Mig , and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types
Koga et al., J Immunol 1999 (Acute Disease) : T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-gamma induced chemokine Mig
Lauw et al., Infect Immun 2000 (Melioidosis) : The production of IP-10 and Mig by various cell types in vitro is strongly dependent on IFN-gamma
Dwinell et al., Gastroenterology 2001 (Bacterial Infections...) : Interferon (IFN)-gamma stimulation increased mRNA expression and the polarized basolateral secretion of these chemokines by human colon epithelial cell lines ; infection with enteroinvasive bacteria, or stimulation with the proinflammatory cytokines tumor necrosis factor alpha and interleukin 1alpha, strongly potentiated IFN-gamma induced epithelial cell IP-10, Mig , and I-TAC production
Park et al., J Immunol 2001 : The results presented herein show that IFN-gamma dependent induction of Mig and Crg-2 gene expression can occur in many nonlymphoid organs, and these genes are rapidly induced in purified hepatocytes isolated from mice treated with IL-2 plus IL-12, or from Hepa 1-6 hepatoma cells treated in vitro with IFN-gamma
Sheikh et al., Ann N Y Acad Sci 2001 : Lysophosphatidylcholine inhibits T cell-specific CXC chemokines IP-10, MIG , and I-TAC expression induced by IFN-gamma in human endothelial cells
Ren et al., Shock 2002 : In the current investigation, MIG and IP-10 mRNA and protein were up-regulated in primary rat hepatocytes in vitro in response to IFNgamma
Ogawa et al., Arthritis Rheum 2002 (Sjogren's Syndrome) : The production of IP-10 and Mig proteins by salivary epithelial cells in response to IFNgamma was determined by ELISA ... These findings suggest that IFNgamma stimulates the production of IP-10 and Mig in the SS ductal epithelium, and that IP-10 and Mig are involved in the accumulation of T cell infiltrates in the SS salivary gland
Arai et al., Cell Immunol 2002 (Adenoviridae Infections...) : It is shown that while IFNgamma induces IP-10 and Mig in hepatocytes, for optimal chemokine induction, a co-stimulatory signal mediated by cross linking of Fas on hepatocytes is required
Hiroi et al., Biochem J 2003 (Carcinoma...) : The human oral squamous carcinoma line Ca9-22 and the glioma line A172 failed to express CXCL9 and CXCL10 mRNAs in response to IFNgamma , whereas other carcinoma lines including HSC-2 did express these mRNAs ... Activation of NF-kappaB in Ca9-22 cells restored the expression of IFNgamma stimulated CXCL9 and CXCL10 mRNAs
Hardaker et al., FASEB J 2004 (Inflammation...) : In primary cultured hASM cells taken from normal donors, CXCL10 protein expression was induced by IFN-gamma and TNF-alpha, cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Hillyer et al., Clin Exp Immunol 2003 : In combination with TNF-alpha, IFN-gamma suppressed CXCL8 but enhanced CCL5 and CXCL10, whereas transforming growth factor ( TGF ) -beta reduced secretion of all chemokines
Fuller et al., Infect Immun 2003 (Granuloma, Respiratory Tract...) : We examined more than 300 granulomas and observed abundant expression of gamma interferon ( IFN-gamma ) -inducible chemokine mRNAs ( CXCL9/monokine induced by IFN-gamma , CXCL10/IFN-gamma-inducible protein, and CXCL11/IFN-gamma-inducible T-cell alpha-chemoattractant ) within solid and caseous granulomas, and there was only minimal expression in nongranulomatous regions of tissue
Proost et al., J Leukoc Biol 2004 (Arthritis, Infectious...) : Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids ... PGN and LPS, but not unmethylated CpG oligonucleotides, even inhibited IFN-gamma induced CXCL9 and CXCL11 expression in leukocytes ... In sharp contrast, in fibroblasts, the TLR ligands PGN, dsRNA, LPS, and flagellin synergized with IFN-gamma for the production of CXCL9 and CXCL11 ... In vitro, IFN-gamma and TLR3 ligation by double stranded RNA ( dsRNA ) induced the expression of CXCL9 and CXCL11 in leukocytes and skin-muscle fibroblasts, whereas ligation of TLR2, TLR4, TLR5, and TLR9 by peptidoglycan ( PGN ), lipopolysaccharide (LPS), flagellin, and unmethylated CpG oligonucleotides, respectively, did not
Whiting et al., J Immunol 2004 : In vitro experiments demonstrated that 1 ) exogenous MIG/CXCL9 stimulated CD4 lymphocyte proliferation in a MHC class II-mismatched MLR, 2 ) MIG/CXCL9 also increased the number of IFN-gamma producing CD4 lymphocytes in ELISPOT, 3 ) neutralization of MIG/CXCL9 in MLR reduced T lymphocyte proliferation, 4 ) IFN-gamma-inducible protein 10/CXCL10 and IFN-inducible T cell alpha chemoattractant/CXCL11 had similar effects on T lymphocyte proliferation, 5 ) MIG/CXCL9 stimulated T lymphocyte proliferation in MHC class I- and total MHC mismatched MLRs, 6 ) neutralization of CXCR3 reduced MIG/CXCL9 induced T lymphocyte proliferation and the number of IFN-gamma positive spots on ELISPOT, and 7 ) the proliferative effects of MIG/CXCL9 were mediated via an IL-2 independent pathway and were controlled by IFN-gamma
Dajotoy et al., J Leukoc Biol 2004 (Crohn Disease) : We found that IFN-gamma induced rapid and sustained gene expression of MIG , IP-10, and I-TAC in eosinophils, as detected by quantitative reverse transcriptase-polymerase chain reaction ... TNF-alpha but not IL-1beta enhanced the IFN-gamma induced production of MIG and IP-10 ... Conversely, addition of the Th2 cytokine IL-4 down-regulated IFN-gamma induced synthesis of MIG and IP-10 in eosinophils
Thomas et al., J Immunol 2004 (Bronchial Hyperreactivity) : In lymphocytes restimulated with CXCL9 and allergen in vitro, CXCL9 down-regulated IL-4 expression and up-regulated IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Sheikh et al., Cardiovasc Res 2005 (Arteriosclerosis) : Lysophosphatidylcholine posttranscriptionally inhibits interferon-gamma induced IP-10, Mig and I-Tac expression in endothelial cells ... Effects of lysoPC on the IFN gamma induced gene expression of IFN-inducible protein of 10 kDa (IP-10), IFN-inducible T cell alpha chemoattractant ( I-Tac ), and monokine induced by IFN gamma (Mig) were evaluated in cultured endothelial cells ... Northern blotting showed that lysoPC transiently and dose-dependently inhibited the IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48, interferon regulatory factor-1 and guanidine binding protein-1 ... LysoPC selectively inhibits IFN gamma induced IP-10, I-Tac and Mig expression in endothelial cells, at least in part, by reducing mRNA stability
McInnis et al., Invest Ophthalmol Vis Sci 2005 : In contrast, stimulation with TNF-alpha, IL-1alpha, or IFN-gamma induced levels of MIG and I-TAC that were not significantly greater than constitutive levels
Tsubaki et al., Clin Exp Immunol 2005 (Arthritis, Rheumatoid) : Furthermore, cultured synovial fibroblasts were confirmed to produce Mig/CXCL9 upon stimulation with IFN-gamma
Pechkovsky et al., Respir Res 2005 : IFN-gamma , alone or in combination with IL-1beta and TNF-alpha resulted in an increase in CXCL10, CXCL11, and CXCL9 mRNA expression and generation of CXCL10 protein by AEC-II or A549 cells
Abramo et al., Microbes Infect 2006 (Tuberculosis) : Since MIG is induced early in the response to IFN-gamma , measuring MIG may provide an interesting marker to assess downstream IFN-gamma induced responses, in contrast to assays that mainly focus on quantifying production of IFN-gamma per se
Zeng et al., Infect Immun 2005 (Klebsiella Infections...) : MIG mRNA expression in the lungs of Klebsiella infected mice required the endogenous production of IFN-gamma , whereas IP-10 was expressed in both an IFN-gamma dependent and an IFN-gamma independent fashion
Ersvaer et al., Cancer Immunol Immunother 2007 (Leukemia, Lymphoid...) : Furthermore, IFNgamma decreased the release of proangiogenic CXCL8 and increased the release of antiangiogenic CXCL9-11
Medoff et al., J Immunol 2006 (Bronchiolitis Obliterans...) : Expression of both CXCL9 and CXCL10 7 days posttransplant is regulated by IFN-gamma and STAT1
Traidl-Hoffmann et al., Int Arch Allergy Immunol 2006 : Keratinocyte cultures established from normal skin of healthy donors were activated by IFN-gamma in the absence or presence of desloratadine and loratadine, and tested for the release of CCL5/RANTES, CXCL8/IL-8 , CCL17/TARC and CXCL10/IP-10 ... Desloratadine and loratadine inhibited the constitutive and IFN-gamma induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged
Bandyopadhyay et al., Biochem Pharmacol 2006 : In addition, apigenin inhibits IFNgamma stimulated secretion of monokines, CXCL-9 , and -10 in MC3T3-E1 cells
Sakaeda et al., Biochem Biophys Res Commun 2006 : Sulindac, a nonsteroidal anti-inflammatory drug, selectively inhibits interferon-gamma induced expression of the chemokine CXCL9 gene in mouse macrophages ... Luciferase reporter assay demonstrated that sulindac inhibited IFNgamma induced promoter activity of the CXCL9 gene
Müller et al., Int J Mol Med 2006 : The Th1 cytokines CXCL9/MIG and CXCL10/IP-10 and the chemokine CCL5/RANTES were regulated in a distinct manner : Whereas histamine inhibited the IFN-gamma/TNF-alpha induced secretion of MIG via the histamine receptor subtypes H1, H2, and H3, the histamine induced suppression of RANTES was due to activation of the H2 and H3 receptors, while reduction of cytokine triggered IP-10 secretion was mediated only by triggering the H2 receptor
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin enhances interferon-gamma induced production of CXC ligand 9 (CXCL9), CXCL10 , and CXCL11 in human keratinocytes ... Prolactin enhances interferon-gamma induced production of CXC ligand 9 (CXCL9) , CXCL10, and CXCL11 in human keratinocytes ... Although prolactin alone was ineffective, it enhanced IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... Although prolactin alone was ineffective, it enhanced IFN-gamma induced secretion and mRNA expression of CXCL9 , CXCL10, and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... Inhibitors of Janus kinase ( JAK ), p38 MAPK, and MAPK/ERK kinase (MEK) suppressed prolactin- plus IFN-gamma induced CXCL9 , CXCL10, and CXCL11 production and NF-kappaB, STAT1, and IRF-1 activities ... These results suggest that prolactin may enhance IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in keratinocytes via activation of STAT1, NF-kappaB, and IRF-1 through JAK2 and MEK/ERK pathways
Kanda et al., Eur J Immunol 2007 : IL-18 enhances IFN-gamma induced production of CXCL9, CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro effects of IL-18 on IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in human keratinocytes ... IL-18 enhanced the IFN-gamma induced secretion and mRNA expression of CXCL9, CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1 ... IL-18 enhanced the IFN-gamma induced secretion and mRNA expression of CXCL9 , CXCL10, and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1 ... Inhibitors of PI3 K, p38 MAPK, and MEK suppressed IL-18 plus IFN-gamma induced CXCL9 , CXCL10, and CXCL11 production and NF-kappaB, STAT1, and IRF-1 activities ... These results suggest that IL-18 may potentiate IFN-gamma induced CXCL9, CXCL10 , and CXCL11 production in keratinocytes by activating NF-kappaB, STAT1, or IRF-1 through PI3 K/Akt and MEK/ERK pathways
Gorbachev et al., J Immunol 2007 (Fibrosarcoma...) : CXC chemokine ligand 9/monokine induced by IFN-gamma production by tumor cells is critical for T cell mediated suppression of cutaneous tumors
Taubert et al., Vet Res Commun 2008 : Furthermore, IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1, CXCL8 , CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Bonville et al., Virology 2007 (Body Weight...) : Although we see no changes in the extent or kinetics of virus replication, we observe diminished local production of inflammatory mediators, including MIP-1alpha, JE/MCP-1, IFN-gamma and IFN-gamma induced MIG and IP-10, and interleukins (IL)-6 and IL-17
Happel et al., Alcohol 2007 (Alcoholic Intoxication...) : IP-10, MIG , and I-TAC in response to LPS were enhanced by exogenous interferon (IFN)-gamma , and these responses were blunted by exposure to ethanol
Ayer et al., J Pharmacol Exp Ther 2008 : In BEAS-2B human airway epithelial cells, taprostene, a selective IP-receptor agonist, suppressed interferon-gamma induced CXCL9 and CXCL10 release in a concentration dependent manner
Sumida et al., Arch Med Res 2008 (Lung Diseases, Interstitial) : However, the induction patterns of chemokines by these two cytokines were different, i.e., involving predominant induction of IP-10 and I-TAC by TNF-alpha and induction of Mig by IFN-gamma
Hofer et al., Viral Immunol 2008 (Lymphocytic Choriomeningitis) : Despite a primary role of interferon (IFN)-gamma in inducing the expression of the CXCL9 gene, and to a lesser extent the CXCL10 gene in LCM, the absence of the IFN-gamma receptor did not influence the disease outcome
Sanmiguel et al., Cell Signal 2009 (Psoriasis) : Inhibition of IRAK1 activity through RNAi or expression of a dominant negative mutant blocked production of CCL5 and CCL20 but had no effect upon the IL-1 enhancement of IFN-gamma induced CXCL9 , CXCL10 and CXCL11 production
Kawaguchi et al., Immunol Lett 2009 (Colonic Neoplasms) : Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-gamma stimulated CXCL9-11 production in intestinal epithelial cells ... IFN-gamma was shown to stimulate CXCL9-11 production, and RNA interference against RIG-I resulted in significant decrease of IFN-gamma induced CXCL9-11 productions
Antonelli et al., J Clin Endocrinol Metab 2009 (Graves Disease...) : It has been studied how IFNgamma and TNFalpha stimulation and PPARgamma activation affect CXCL9 and CXCL11 secretion in primary cultures of thyrocytes, orbital fibroblasts, and preadipocytes
Milks et al., Liver Int 2009 (Disease Models, Animal...) : Ifng is dichotomous in the regulation of distinct chemokine subfamilies : specifically, Ifng is critical for overexpression of specific CXCL genes but dispensable for overexpression of specific CCL genes
Amin et al., J Infect Dis 2009 (Trypanosomiasis, African) : CXCL9 and CXCL10 mRNA accumulation was interferon (IFN)-gamma dependent
Rosenblum et al., J Immunol 2010 : CXCL9 , but not CXCL10, expression required NK cell production of IFN-gamma
Chung et al., J Pharmacol Sci 2010 (Inflammation) : alpha-Viniferin at 3 - 10 muM dose-dependently inhibited IFN-gamma induced production of NO, IFN-gamma-inducible protein-10 (IP-10), or the monokine induced by IFN-gamma (MIG) in RAW 264.7 cells and also that of NO in primary macrophages derived from C57BL/6 mice
Ellis et al., J Immunol 2010 : The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1 ... In cultured glial cells, the induction of the CXCL9 ( in microglia ) and CXCL10 ( in microglia and astrocytes ) mRNAs by IFN-gamma was not inhibited by cycloheximide ... STAT1 was critical for IFN-gamma induction of both the Cxcl9 and Cxcl10 genes in microglia and in microglia and astrocytes, respectively ... The small interfering RNA mediated knockdown of PU.1 in microglia markedly impaired IFN-gamma induced CXCL9 but not STAT1 or IFN regulatory factor-8 ... Cells of the D1A astrocyte line showed partial reprogramming to a myeloid-like phenotype posttransduction with PU.1 and, in addition to the expression of CD11b, acquired the ability to produce CXCL9 in response to IFN-gamma ... Thus, PU.1 not only is crucial for the induction of CXCL9 by IFN-gamma in microglia but also is a key determinant factor for the cell-specific expression of this chemokine by these myeloid cells
Farber et al., Biochem Biophys Res Commun 1993 : Humig is induced in THP-1 cells and in peripheral blood mononuclear cells by interferon-gamma but not by interferon-alpha or by lipopolysaccharide
Lerner et al., EMBO J 1996 : IFN-gamma secretion from the CD4+CD8+TCRlow thymocytes regulates macrophage Mig production
Ohmori et al., J Biol Chem 1998 (Inflammation) : IL-4 suppressed IFNgamma induced expression of the MIG ( monokine induced by IFNgamma ) gene, a C-X-C chemokine, in mouse macrophages
Horton et al., J Biol Chem 1998 : The purpose of this investigation was to determine the effect of hyaluronan ( HA ) on IFN-gamma induced Mig and IP-10 expression in mouse macrophages