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CXCL16 — IFNG
Text-mined interactions from Literome
Hardaker et al., FASEB J 2004
(Inflammation...) :
In primary cultured hASM cells taken from normal donors,
CXCL10 protein expression was
induced by
IFN-gamma and TNF-alpha, cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Hillyer et al., Clin Exp Immunol 2003
:
In combination with TNF-alpha,
IFN-gamma suppressed
CXCL8 but enhanced CCL5 and CXCL10, whereas transforming growth factor ( TGF ) -beta reduced secretion of all chemokines
Yamauchi et al., Arterioscler Thromb Vasc Biol 2004
(Endocarditis, Bacterial...) :
Furthermore,
SR-PSOX/CXCL16 stimulated
interferon-gamma (IFN-gamma) production by CD8+ T cells
Wuttge et al., Arterioscler Thromb Vasc Biol 2004
(Arteriosclerosis...) :
We investigated whether
CXCL16 expression is
controlled by
interferon-gamma (IFN-gamma)-cytokine abundant in atherosclerotic lesions ... In vitro
IFN-gamma induced
CXCL16 in human monocytic THP-1 cells and primary human monocytes, which led to increased uptake of oxidized low-density lipoprotein in THP-1 cells, which could be blocked by peptide antibodies against CXCL16
Thomas et al., J Immunol 2004
(Bronchial Hyperreactivity) :
In lymphocytes restimulated with CXCL9 and allergen in vitro,
CXCL9 down-regulated IL-4 expression and up-regulated
IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Wågsäter et al., Biochem Biophys Res Commun 2004
(Arteriosclerosis) :
The chemokine and scavenger receptor
CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is
induced by
interferon gamma ...
IFN-gamma was the most potent CXCL16 inducer and
increased mRNA, soluble form, membrane form, and total cellular levels of
CXCL16 ... The
IFN-gamma induction of
CXCL16 was also associated with increased uptake of oxLDL into these cells
Nanki et al., Arthritis Rheum 2005
(Arthritis, Rheumatoid) :
Stimulation with interleukin-15 (IL-15) up-regulated the expression of CXCR6 on peripheral blood T cells, and then stimulation with
CXCL16 induced migration of IL-15 stimulated T cells and enhanced
IFNgamma production
Traidl-Hoffmann et al., Int Arch Allergy Immunol 2006
:
Keratinocyte cultures established from normal skin of healthy donors were
activated by
IFN-gamma in the absence or presence of desloratadine and loratadine, and tested for the release of CCL5/RANTES,
CXCL8/IL-8 , CCL17/TARC and CXCL10/IP-10 ... Desloratadine and loratadine inhibited the constitutive and
IFN-gamma induced release of CCL5,
CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged
Bandyopadhyay et al., Biochem Pharmacol 2006
:
In addition, apigenin inhibits
IFNgamma stimulated secretion of monokines,
CXCL-9 , and -10 in MC3T3-E1 cells
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Prolactin enhances
interferon-gamma induced production of CXC ligand 9 (CXCL9),
CXCL10 , and CXCL11 in human keratinocytes ... Although prolactin alone was ineffective, it enhanced
IFN-gamma induced secretion and mRNA expression of CXCL9,
CXCL10 , and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... These results suggest that prolactin may enhance
IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in keratinocytes via activation of STAT1, NF-kappaB, and IRF-1 through JAK2 and MEK/ERK pathways
Kanda et al., Eur J Immunol 2007
:
IL-18 enhances
IFN-gamma induced production of CXCL9,
CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro effects of IL-18 on
IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in human keratinocytes ... IL-18 enhanced the
IFN-gamma induced secretion and mRNA expression of CXCL9,
CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1 ... These results suggest that IL-18 may potentiate
IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in keratinocytes by activating NF-kappaB, STAT1, or IRF-1 through PI3 K/Akt and MEK/ERK pathways
Taubert et al., Vet Res Commun 2008
:
Furthermore,
IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1,
CXCL8 , CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Tohyama et al., Int Immunol 2007
:
Stimulation with tumor necrosis factor alpha, IL-1alpha,
IFN-gamma , peptidoglycan and polyinosinic-polycytidylic acid [ poly ( I:C ) ]
enhanced CXCL16 production
Milks et al., Liver Int 2009
(Disease Models, Animal...) :
Ifng is dichotomous in the regulation of distinct chemokine subfamilies : specifically,
Ifng is
critical for overexpression of specific
CXCL genes but dispensable for overexpression of specific CCL genes