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HNRNPF — IFNB1
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Huang et al., Cytokine 2001
:
IFN-beta dose-dependently
increased IL-3Ralpha+
DCs and decreased CD1a+ DCs
Liu et al., J Immunol 2001
:
The up-regulation of TRAIL on
IFN-beta stimulated
DCs partially contributed to the increased cytotoxicity of DCS : Pretreatment of TRAIL-sensitive tumor cells with caspase-3 inhibitor could significantly increase their resistance to the cytotoxicity of IFN-beta stimulated DCS : In contrast, NF-kappaB inhibitor could significantly increase the sensitivity of tumor cells to the killing by nonstimulated or LPS stimulated DCS : Our studies demonstrate that IFN-beta stimulated DCs are functionally cytotoxic
Huang et al., Clin Exp Immunol 2001
(Multiple Sclerosis) :
IFN-beta and IL-10
inhibited the costimulatory capacity of
DCs in mixed lymphocyte reaction (MLR) and showed additive effects on suppression of IL-12 production by DCs
Vidalain et al., J Immunol 2001
:
However, IFN-alpha- or IFN-gamma stimulated CD11c+ blood DCs and
IFN-beta stimulated monocyte derived
DCs were recently reported to express functional TNF related apoptosis inducing ligand ( TRAIL ), suggesting that DCs may become cytotoxic effector cells of innate immunity upon appropriate stimulation
Wiesemann et al., J Neuroimmunol 2002
:
The
effects of
interferon beta (IFN-beta) , an immunomodulatory cytokine used in multiple sclerosis (MS) therapy, on
DCs are not well understood ... Moreover,
IFN-beta enhanced the capacity of
DCs to stimulate autologous T-cells to secrete IL-13, IL-10 and IL-5
Kaiser et al., J Exp Med 2009
:
In contrast, CpG
induction of both IFN-alpha and
IFN-beta by plasmacytoid
DCs was decreased in the absence of TPL-2, although extracellular signal regulated kinase ( ERK ) activation was blocked
Ramgolam et al., J Immunol 2009
(Multiple Sclerosis) :
We have investigated the
effect of
IFN-beta-1a on
dendritic cells (DCs) and naive CD4 ( + ) CD45RA ( + ) T cells derived from untreated MS patients and healthy controls in the context of Th17 cell differentiation
Yen et al., J Immunol 2010
:
In vivo treatment with
IFN-beta results in lower numbers of
DCs migrating to the draining lymph node following exposure to FITC and in reduced expression of CCR7 and MMP-9 in splenic CD11c ( + ) DCs following LPS administration
Hoshino et al., J Immunol 2010
:
In this study, we showed that IKKalpha was
required for production of
IFN-beta , but not of proinflammatory cytokines, by TLR7/9 stimulated conventional
DCs