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MAP2K2 — PTGS2

Text-mined interactions from Literome

Yan et al., J Biol Chem 2000 : B [ a ] P caused a rapid increase in phosphorylation of extracellular signal regulated kinase ( ERK ) ; pharmacologic inhibition of mitogen activated protein kinase kinase blocked B [ a ] P-mediated induction of COX-2
Kulkarni et al., Clin Cancer Res 2001 (Adenocarcinoma...) : The induction of COX-2 by EGF was suppressed by inhibitors of tyrosine kinase activity, phosphatidylinositol 3-kinase, mitogen activated protein kinase kinase , and p38 mitogen activated protein kinase
Marrache et al., J Immunol 2002 : COX-2 expression was prevented by mitogen activated protein kinase kinase/extracellular signal regulated kinase 1/2 and NF-kappaB inhibitors
Liu et al., Am J Respir Cell Mol Biol 2007 : EGF receptor (EGFR) inhibition, neutralizing antibody against amphiregulin, or mitogen activated protein kinase kinase ( MEK ) inhibition blocked TGF-beta1 mediated COX-2 induction
Zhang et al., Mol Cancer Res 2008 (Carcinoma, Squamous Cell...) : In HNSCC cells, the bradykinin induced expression of COX-2 was inhibited by the EGFR kinase inhibitor gefitinib or mitogen activated protein kinase kinase inhibitors ( PD98059 or U0126 )
Kang et al., Cancer prevention research (Philadelphia, Pa.) 2008 (Cell Transformation, Neoplastic) : Here, we report that delphinidin, a major dietary anthocyanidin, inhibits tumor promoter induced transformation and cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal ( JB6 P+ ) cells by directly targeting Raf and mitogen activated protein kinase kinase ( MEK )