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EDN1 — MYO10

Text-mined interactions from Literome

Kernochan et al., Gut 2002 : Endothelin-1 stimulates colonic subepithelial myofibroblast contraction and migration via endothelin receptor mediated myosin phosphorylation
Saab et al., J Biomed Sci 2002 : Y-27632, which selectively inhibits rho associated kinase, also blocked endothelin-1 stimulated myosin phosphorylation and contractile force generation with a similar dose dependence
Ansari et al., Cell Signal 2004 : Involvement of Ca2+ channels in endothelin-1 induced MAP kinase phosphorylation, myosin light chain phosphorylation and contraction in rabbit iris sphincter smooth muscle
Polte et al., Am J Physiol Cell Physiol 2004 : When pulmonary VSM cells were cultured on increasing densities of immobilized fibronectin ( FN ), cell spreading, myosin light chain ( MLC ) phosphorylation, cytoskeletal prestress ( isometric tension in the cell before vasoagonist stimulation ), and the active contractile response to the vasoconstrictor endothelin-1 all increased in parallel
Zubkov et al., J Cardiovasc Pharmacol 2004 : The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor, damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished endothelin-1 induced contraction and MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced endothelin-1 induced RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Melton et al., Am J Physiol Gastrointest Liver Physiol 2006 : Removal of extracellular Ca2+ did not alter endothelin-1 stimulated force development or [ Ca2+ ] i. Ionomycin, a Ca2+ ionophore, triggered an increase in [ Ca2+ ] i that was three times greater than that stimulated by endothelin-1, but only induced 16 % of the force and 38 % of the myosin regulatory light chain ( MLC ) phosphorylation induced by endothelin-1
Abe et al., Jpn J Pharmacol 1991 : Endothelin-1 (ET) , a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips
Szeto et al., Arch Biochem Biophys 1996 : Comparison of the time courses of myosin phosphorylation at optimal ( Lo ) and preshortened lengths indicated that the initial peak myosin phosphorylation induced by K ( + ) -depolarization, histamine, and endothelin were all length dependent ... The different length dependences of depolarization- and endothelin induced myosin phosphorylation were found to correlate with different length-force relations