Yoshimoto et al., J Immunol 2008
(Melanoma, Experimental) :
IL-27 augmented the expression of IFN regulatory factor (IRF)-1 and IRF-8 , which possess tumor suppressor activities, in B16F10 transfectants expressing wild-type WSX-1
Zhang et al., J Biol Chem 2010
(Inflammation) :
Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1 ... Consistent with this observation, overexpression of both IRF-8 and IRF-1 additively activated IL-27 p28 promoter