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MAP2K1 — PAK2

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → MAP2K1 (protein-protein, phosphorylation)
• WikiPathways Focal Adhesion: PAK1/PAK3/PAK2/PAK4/PAK7/PAK6 → SEPP1/MAP2K5/MAP2K6/MAP2K2/MAP2K3/MAP2K1 (activation)
  

Text-mined interactions from Literome

Slack-Davis et al., J Cell Biol 2003 : We propose that FAK/Src dependent, PAK1 mediated phosphorylation of MEK1 on S298 is central to the organization and localization of active Raf-MEK1-MAPK signaling complexes, and that formation of such complexes contributes to the adhesion dependence of growth factor signaling to MAPK
Beeser et al., J Biol Chem 2005 : Inhibition of Pak kinase activity dramatically decreased phosphorylation of Mek1 at Ser ( 298 ) in response to either PDGF or EGF, but this inhibition did not prevent Mek1 activation by EGF, suggesting that although Pak can phosphorylate Mek1 at Ser ( 298 ), this event is not required for Mek1 activation by growth factors
Park et al., Cell Signal 2007 : MEK1 activation by PAK : a novel mechanism ... Here we provide evidence that PAK can directly activate MEK1 by a mechanism distinct from conventional Ras/Raf mediated activation ... We find that PAK phosphorylation of MEK1 serine 298 stimulates MEK1 autophosphorylation on the activation loop, and activation of MEK1 activity towards ERK in in vitro reconstitution experiments ... Serines 218 and/or 222 in the MEK1 activation loop are required for PAK stimulated MEK1 activity towards ERK