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GATA2 — IRF6

Text-mined interactions from Literome

Simoncini et al., Circ Res 2000 : Consistently, gel-shift assays showed that E ( 2 ) and Dex comparably inhibit LPS induced activation of NF-kappaB, whereas E ( 2 ) inhibited LPS induced activation of AP-1 and GATA to a greater extent than Dex
El Gazzar et al., Inflamm Res 2007 : Chromatin immunoprecipitation revealed that GATA, AP-1 and NF-AT binding to IL-5 promoter was induced by LPS stimulation and that TQ inhibited GATA binding at the IL-5 promoter but did not affect AP-1 and NF-AT binding
Wu et al., PloS one 2013 : GATA-2 Transduces LPS Induced il-1ß Gene Expression in Macrophages via a Toll-Like Receptor 4/MD88/MAPK-Dependent Mechanism ... LPS could enhance the transactivation activity of GATA-2 in macrophages ... Sequentially, treatment with myeloid differentiation factor 88 ( MyD88 ) siRNA decreased LPS induced phosphorylation of mitogen activated protein kinases ( MAPKs ) kinase 1/2 and subsequent translocation of GATA-2 ... Results of this study show that LPS induction of il-1ß gene expression in macrophages is mediated by GATA-2 via activation of TLR4, MyD88, and MAPKs