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CDCA5 — IRF6
Text-mined interactions from Literome
Perera et al., J Immunol 2001
:
Therefore, the relative contribution of these proteins in the induction of cyclooxygenase 2 (COX-2), IL-12
p35 , IL-12 p40, TNF-alpha, IFN-inducible protein (IP)-10, and IFN consensus sequence binding protein ( ICSBP ) genes in
response to LPS or the
LPS-mimetic , Taxol, was examined using macrophages derived from mice deficient for these membrane associated proteins
Maruyama et al., J Immunol 2003
:
While IFN-gamma must be present for IL-12 p40 gene induction, the
p35 gene is strongly
induced by
LPS , even in the absence of IFN-gamma, and therefore the induction of the p35 gene is IRF-1 independent
Petro et al., Int Immunopharmacol 2003
:
In contrast, STE had no effect on
LPS induced
p35 and p40 promoter activity and diminished IFN-gamma/LPS induced p35 promoter activity
Goodridge et al., Immunology 2003
(MAP Kinase Signaling System) :
We now define distinct signalling mechanisms that regulate
lipopolysaccharide (LPS) mediated induction of IL-12 p40 and
p35 in macrophages and which may therefore provide therapeutic targets for precise and specific fine tuning of cytokine responses
Obata et al., Scand J Immunol 2006
:
This was confirmed by mRNA analysis, which showed that H ( 2 ) O ( 2 ) increased
LPS induced mRNA expression of both IL-12p40 and
IL-12p35 subunits with an increased p40/p35 ratio
Qi et al., Sci China C Life Sci 2000
:
It was found that IFN-gamma strongly enhanced the
LPS induced IL-12 p40 and
p35 mRNA expression
Hayes et al., Blood 1995
:
Time course experiments demonstrated independent
regulation of p40 and
p35 by IFN-gamma and
LPS ... Finally, both p40 and
p35 were directly
induced by
LPS in the presence of cycloheximide
Cassatella et al., Eur J Immunol 1995
:
Therefore, the combined effect of
LPS and IFN-gamma
induced sufficient expression of both p40 and
p35 to attain production of the biologically active p70 heterodimer at physiologically relevant concentrations
Salkowski et al., Infect Immun 1997
:
LPS was a more potent
inducer of IL-12
p35 , IL-12 p40, and IFN-gamma mRNA, as well as of IL-12 protein, than MPL