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HRAS — INSR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) → HRAS/GTP complex (HRAS) (modification, activates) Wick et al., J Biol Chem 2001, Ouwens et al., J Biol Chem 1994, Yamauchi et al., J Biol Chem 1994, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates) Wick et al., J Biol Chem 2001, Ouwens et al., J Biol Chem 1994, Yamauchi et al., J Biol Chem 1994, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GTP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GDP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HRAS — INSR (direct interaction, enzymatic study) O'Brien et al., FEBS Lett 1987*
• IRef Hprd Interaction: HRAS — INSR (in vitro) O'Brien et al., FEBS Lett 1987*
• IRef Ophid Interaction: HRAS — INSR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: INSR — HRAS (interaction, mapped from grid kegg_pathways dip mint intact)
• STRING interaction: INSR — HRAS (interaction, mapped from grid kegg_pathways dip mint intact)
• STRING interaction: HRAS — INSR (interaction, mapped from kegg_pathways mint intact)
• STRING interaction: HRAS — INSR (interaction, mapped from kegg_pathways mint intact)

Text-mined interactions from Literome

Baron-Delage et al., Bull Cancer 1994 (Carcinoma...) : This is the first evidence that, when oncogenically activated, p21ras and pp60c-src not only exert a negative control on insulin receptor function but also repress insulin receptor gene expression in human colonic cells
Myers et al., Mol Cell Biol 1994 : Coexpression of IRS-1 or IRS-1F-895 with the insulin receptor was required for insulin stimulated mitogenesis in 32-D cells, while expression of the insulin receptor alone was sufficient to mediate insulin stimulated tyrosine phosphorylation of Shc and activation of p21ras and mitogen activated protein ( MAP ) kinase