den Besten et al., Nature structural & molecular biology 2012
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Previous analysis has linked the p97 pathway to cullin-RING ubiquitin ligases ( CRLs ) ; here we demonstrate that the human p97 cofactor UBXD7 mediates the p97-CRL interaction through its conserved ubiquitin interacting motif ( UIM )
Bandau et al., BMC biology 2012
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In particular, human UBXN7 ( also known as UBXD7 ) mediates p97 interaction with the transcription factor HIF1a that is actively ubiquitylated in normoxic cells by a CUL2 based E3 ligase, CRL2