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IFNB1 — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IFNG → IFNB1 (increases)
  Evidence: IFNbeta altered the IFNgamma cytokine profile in unfractionated Peripheral blood mononuclear cells (PBMCs) primed in vitro with Myelin basic protein, The production of IFNgamma was augmented in culture (59pg/ml versus 105pgml).

Text-mined interactions from Literome

Cousens et al., J Exp Med 1999 (Lymphocytic Choriomeningitis) : Under normal conditions of infections, the CD8 T cell IFN-gamma response was dependent on endogenous IFN-alpha/beta effects, but was IL-12 independent
Bakhiet et al., Clin Diagn Lab Immunol 1999 (Multiple Sclerosis) : The present work confirms in vivo the in vitro suppressive effects of IFN-beta-1b on IFN-gamma production in MS
Cremer et al., J Immunol 2000 : The constitutive IFN-beta production also resulted in an increased production of IL-12 and IFN-gamma Th1-type cytokines and of the beta-chemokines macrophage-inflammatory protein-1alpha, macrophage-inflammatory protein-1beta, and RANTES
Khademi et al., J Neuroimmunol 2000 (Multiple Sclerosis, Relapsing-Remitting) : These effects were not apparent after 2 weeks of treatment, and IFNbeta-1a induced IFNgamma production by naive PBMC in vitro
Nguyen et al., Nat Immunol 2000 (Virus Diseases) : They also show that type 1 interferon signaling can occur through STAT1 dependent and independent mechanisms and suggest that efficient induction of IFN-gamma expression by IFN-alpha/beta requires STAT1 regulation
Krug et al., Eur J Immunol 2001 : IFNgamma production in PBMC was dependent on CpG ODN induced IFN-alpha/beta as demonstrated by IFN-alpha/beta blocking antibodies
Mitani et al., Genes Cells 2001 : Previously, we reported on the critical role of the IFN-alpha/beta signalling complex, generated by spontaneously produced IFN-alpha/beta, in efficient IFN-gamma signalling
Iarlori et al., J Neuroimmunol 2002 (Multiple Sclerosis...) : IFNbeta-1b , in vitro, increases MCP-1, TNFalpha and IFNgamma spontaneous production in all patients
Costa-Pereira et al., J Virol 2002 : Accordingly, possible roles for autocrine or double-stranded-RNA ( dsRNA ) -induced IFN-alpha/beta in the IFN-gamma response were investigated ... IFN-gamma did not induce detectable levels of IFN-alpha/beta in any of the cell lines, nor was the IFN-gamma response per se dependent on autocrine IFN-alpha/beta
Soos et al., J Immunol 2002 (Encephalomyelitis, Autoimmune, Experimental) : Whereas IFN-alpha and -beta induced IFN-gamma secretion, a Th1 cytokine, IFN-tau did not
Nguyen et al., Science 2002 (Arenaviridae Infections) : Here we show that IFN-alpha/beta activate STAT4 directly ( STAT, signal transducers and activators of transcription ) and that this is required for IFN-gamma production during viral infections of mice, in concert with T cell receptor derived signals ... In contrast, STAT1 appears to negatively regulate IFN-alpha/beta induction of IFN-gamma
Hua et al., J Neurochem 2002 : Electrophoretic mobility shift analysis ( EMSA ) demonstrated that IFN-gamma induced sustained IFN-gamma activated sequence ( GAS ) binding, while IFN-beta induced transient GAS binding
Malmgaard et al., J Gen Virol 2003 (Herpes Simplex) : Interferon (IFN)-alpha/beta , interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2
Gobl et al., Scand J Immunol 1992 : IFN-gamma had only a minor reversing effect on the rIL-4 inhibition, but if cells were precultivated in medium with or without IFN-gamma for 6 h before SV induction, rIL-4 paradoxically enhanced the IFN-alpha/beta response
Une et al., Clin Exp Immunol 2003 (Chagas Disease) : Role of IFN-alpha/beta and IL-12 in the activation of natural killer cells and interferon-gamma production during experimental infection with Trypanosoma cruzi
Peters et al., Immunology 2003 : Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes induced up-regulation of IFN-gamma, IL-1beta and TGF-beta transcripts, and down-regulation of IFN-alpha, IFN-beta and IL-2 transcripts, with a higher induction of IFN-gamma , IL-1beta and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+, TCR2+, or TCR3+ ) subsets
Strengell et al., J Leukoc Biol 2004 : In addition, IFN-alpha/beta enhanced T cell receptor stimulation induced IL-21 and IFN-gamma gene expression in resting T cells
Mattner et al., J Immunol 2004 (Disease Progression...) : IFN-beta treatment of BALB/c mice restored the NK cell cytotoxic activity, increased the lymphocyte proliferation, and augmented the production of IFN-gamma and IL-12 in the draining lymph node ... The IFN-beta induced increase of IFN-gamma production was dependent on STAT4
Marziali et al., J Virol 1991 (Leukemia, Erythroblastic, Acute) : Treatment of Friend erythroleukemia cells ( FLC ) with gamma interferon ( IFN-gamma ) in the presence of anti-IFN-beta antibodies reduces the effectiveness of the antiviral state and the induction of 2'-5'-oligoadenylate synthetase activity, indicating that the antiviral activity of IFN-gamma in FLC is in part mediated by the production of IFN-beta ... These results indicate that posttranscriptional mechanisms are involved in the regulation of IFN-beta and -alpha expression by IFN-gamma
Nozell et al., J Immunol 2006 (Astrocytoma) : IFN-gamma-inducible protein-10 and MCP-1 genes, also regulated by NF-kappaB, are unaffected by IFN-beta , and IFN-beta does not prevent the activation, nuclear migration, or binding of NF-kappaB p65 to the kappaB element of the IFN-gamma-inducible protein-10 promoter
Fahey et al., J Leukoc Biol 2007 : However, despite this up-regulation, IFN-beta suppressed IL-12 induced IFN-gamma expression
Hamamcioglu et al., Mult Scler 2007 (Disease Progression...) : IFN-beta in vitro strongly induced IL-10 and IFN-gamma in activated T cells in RRMS, but not in progressive MS, suggesting IFN resistance
Arakura et al., J Immunol 2007 (Disease Models, Animal...) : Notably, IFN-gamma expression as well as spontaneous IFN-alpha/IFN-beta responses were up-regulated several fold spontaneously in the skin in IRF-2 ( -/- ) BN mice but not in IRF-2 ( -/- ) mice with `` resistant '' backgrounds
Le-Thi-Phuong et al., Int Immunol 2007 (Arterivirus Infections...) : In sharp contrast with other viral infections, IFN-alpha/beta diminished IFN-gamma production and the resulting increased response to LPS in LDV infected animals
Feduchi et al., Virology 1991 : Antibodies against IFN beta block this synergism, implying a role of IFN beta in the antiviral activity of TNF plus IFN gamma
Hedegaard et al., Clin Immunol 2008 (Multiple Sclerosis) : Thus, IFN-beta inhibits IFN-gamma production in general, presumably alleviating the detrimental influence of IFN-gamma in MS
Shirahata et al., Nihon juigaku zasshi. The Japanese journal of veterinary science 1990 (Disease Susceptibility...) : Cs-A did not suppress the production of intereferon(IFN)-alpha/beta that was induced shortly after the infection, whereas it reduced greatly the ability of Toxoplasma infected mice to produce IFN-gamma induced by stimulation with Toxoplasma lysate antigen ( TLA )
Blanchard et al., Infect Immun 1985 : In whole-spleen cultures that were allowed to age for 24 to 48 h before stimulation, F-1 was seen to induce mostly IFN-gamma , with low levels of IFN-alpha/beta present
Nickoloff et al., J Invest Dermatol 1987 : The binding of human IFN-gamma , to keratinocytes was inhibited by human r-IFN-gamma, but not by either murine recombinant gamma interferon or human recombinant beta interferon ( r-IFN-beta )
Gessani et al., J Virol 1989 : Secretion of IFN-beta is also induced in PM by IFN-gamma ... These cells are induced to secrete IFN-beta by LPS but not by IFN-gamma , suggesting that this cytokine may elicit such specific response only in PM. IFN-beta mRNA is undetectable in untreated RAW 264.7 cells, and accumulation of this mRNA is induced by LPS but not by IFN-gamma ... The induction of IFN-beta by IFN-gamma appears to be a characteristic response of PM and may be at least in part responsible for the resistance of these cells to viral infections
Nakane et al., Infect Immun 1988 (Listeriosis) : The effect of endogenous TNF on antilisterial resistance was due to neither regulation of alpha interferon ( IFN-alpha ) and IFN-gamma production nor induction of IFN-beta subtype 1 (IFN-beta 1) , because anti-TNF antibody treated-mice produced normal levels of IFN-alpha and IFN-gamma in the bloodstream during infection and administration of monoclonal anti-murine IFN-beta 1 antibody had no effect on the development of listeriosis
Watanabe et al., Immunology 1988 : The results show that IFN-beta strongly suppressed the induction of IFN-gamma mRNA transcription and, interestingly, profoundly decreased the steady-state level of the T-cell receptor beta-chain ( TCR beta ) gene mRNA without any substantial effect on some other gene expressions, such as those of the interleukin-2 (IL-2) and the major histocompatibility complex ( MHC ) class I genes
Capobianchi et al., Hum Immunol 1985 (Melanoma) : The results can be summarized as follows : class II molecules are markedly increased by IFN gamma ; IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect
Fleischmann et al., J Interferon Res 1984 (Melanoma) : Further, the antiviral and anticellular activities of IFN-alpha and IFN-beta were potentiated equally by IFN-gamma
Weinberg et al., Proc Natl Acad Sci U S A 1984 : The effect was seen with both recombinant IFN-gamma and natural IFN-gamma produced by Staphylococcal enterotoxin A-stimulated lymphocytes, but IFN-alpha ( leukocyte derived and recombinant ) and IFN-beta did not induce MP formation
Ma et al., Infect Immun 1994 : As tumor necrosis factor alpha, IFN-beta , and IL-12 are potent activators of IFN-gamma production by T and NK cells, their presence in these cocultures could be responsible for the IFN-gamma production
Kadereit et al., J Interferon Res 1994 : For example, in HeLa cells, IFN-alpha or IFN-beta induced similarly both PKR and p48 whereas IFN-gamma induced mainly p48
Huang et al., Diabetes 1995 (Diabetes Mellitus, Type 1) : In contrast, IFN-beta was detected at comparable levels in both groups, while IFN-gamma was detected in three of four control pancreases and one of four pancreases from the diabetic individuals
Dalsgaard et al., Placenta 1995 (Pregnancy Complications, Neoplastic...) : Tro-IFN-beta , -alpha and leu-IFN-alpha induced high levels of 2-5A synthetase activity in placental fibroblast, BeWo and FEG-3 cell-lines, whereas rec-IFN-gamma treatment did not induce 2-5A synthetase activity in any of these cells
Le et al., Int J Cancer 1995 (Adenocarcinoma...) : Expression of sHLA is unlikely to result from IFN-gamma induced enhancement of overall HLA-class-I expression, as at low concentrations IFN-alpha, IFN-beta and IFN-gamma stimulated increased expression of cell membrane HLA-class-I molecules in Colo205 cells with almost equal efficiency, whereas only IFN-gamma induced high level production of sHLA
Zhou et al., J Interferon Cytokine Res 1995 (Leukemia L1210) : In the present study, the effect of exogenous IFN-gamma on the induction of endogenous mRNA synthesis and secretion of IFN-alpha/beta by murine M phi was investigated ... These data indicate that exogenous IFN-gamma induces endogenous synthesis and secretion of IFN-alpha/beta by M phi, which appears to act in concert with endogenously synthesized TNF-alpha for the autocrine induction of NOS mRNA synthesis
Miller et al., J Neuroimmunol 1996 (Autoimmune Diseases...) : Basal expression of ICAM-1 molecules was enhanced by TNF alpha and to a lesser extent by IFN-beta , but was not affected by IFN-gamma
Kolosov et al., J Interferon Cytokine Res 1996 : Previous studies suggested that IFN-gamma induced endogenous synthesis of IFN-alpha/beta by murine macrophages ... We tentatively conclude that IFN-gamma stimulates macrophage synthesis and secretion of IFN-alpha/beta , which in turn promotes C1q mRNA synthesis in an autocrine or paracrine manner
Cousens et al., Proc Natl Acad Sci U S A 1997 (Cytomegalovirus Infections...) : Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection ... Both IFN-alpha and IFN-beta inhibited fixed Staphylococcus aureus Cowan strain induction of IL-12 and IFN-gamma production by mouse splenic leukocytes in culture
Arnason et al., J Neural Transm Suppl 1997 (Demyelinating Diseases...) : IFN beta-1b also inhibits release of lymphotoxin, tumor necrosis factor, and interferon gamma , at least in vitro
Hunter et al., Immunol Lett 1997 : IFN-alpha/beta alone stimulated low levels of IFN-gamma production by purified populations of IL-2 activated NK cells but in combination with IL-12 resulted in the production of significant levels of IFN-gamma ... Further studies revealed that TNF-alpha enhanced the ability of IFN-alpha/beta to stimulate production of IFN-gamma by NK cells ... In contrast to the stimulatory effect of IFN-alpha/beta on NK cell production of IFN-gamma , IFN-alpha/beta inhibited IL-2 induced proliferation of NK cells
Revel et al., Mult Scler 1995 (Breast Neoplasms...) : In addition, study of MS patients treated with natural IFN-beta shows that IFN-beta significantly reduces serum levels of IFN-gamma while increasing IL-4, strongly suggesting that IFN-beta also controls the relative activation of TH1- and TH2-type T lymphocytes
Satoh et al., Mult Scler 1996 : The antagonistic effect of IFN-alpha/IFN-beta on the growth promoting activity of IFN-gamma in cultured human astrocytes suggests that interferons serve as growth regulators of astrocytes at sites of reactive gliosis lesions of MS
Asipu et al., Biochim Biophys Acta 1998 : In OL, IFN-alpha/beta caused little induction of CAT activity, but IFN-gamma resulted in a 2-3.5-fold decrease in CAT activity
Weber et al., Ann Neurol 1998 (Multiple Sclerosis) : In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline ( PTX ) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin ( LT ), and interferon-gamma (IFN-gamma)
Van Weyenbergh et al., J Immunol 1998 (Multiple Sclerosis) : In view of the antagonism of IFN-beta on IFN-gamma action, of interest in the chronic inflammatory disorder multiple sclerosis, we examined the possible effect of IFN-beta on IFN-gamma induction of Fc gamma RI gene expression
Liu et al., J Immunol 1998 : However, IFN-gamma also suppresses the expression of IFN-beta- and IL-4 induced IL-1Ra so that IFN-gamma may enhance or suppress IL-1 activity depending on the other cytokines present
Mahalingam et al., J Virol 1999 : MuMig ( murine monokine induced by gamma interferon ) and Crg-2 ( cytokine responsive gene 2 ) are two murine chemokines of the CXC family that are induced by the interferons ( IFNs ) : MuMig specifically by IFN-gamma and Crg-2 by IFN-alpha, IFN-beta , and IFN-gamma