◀ Back to SRC

PHKA2 — SRC

Text-mined interactions from Literome

Blaukat et al., J Biol Chem 1999 : Pyk2 induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb2 and Crk, respectively, and for the activation of ERK and JNK cascades
Tang et al., J Biol Chem 2000 : We found that the Ang II-induced tyrosine phosphorylation of Pyk2 , which requires the activity of Src family kinase, was specifically regulated by the Src family kinase member, Yes kinase
Lakkakorpi et al., J Cell Sci 2001 (Bone Resorption) : We have previously reported that engagement of ( alpha)(v)(beta)(3) integrin in osteoclasts induces tyrosine phosphorylation and activation of the adhesion kinase PYK2 and the adaptor protein p130 ( Cas ) in a Src dependent manner
Iwasaki et al., Endocrinology 2001 : These data suggest that AM stimulates PYK2 which, in turn, activates c-Src and induces recruitment of adaptor proteins ( Shc/Grb2 ), thereby leading to activation of p21(ras)/ERK1/2 cascade in VSMC
Ghosh et al., American journal of physiology. Renal physiology 2001 (MAP Kinase Signaling System) : These data suggested that AVP stimulated Pyk2 tyrosine phosphorylation to activate c-Src , thereby leading to EGF-R transactivation
Roy et al., J Cell Biochem 2002 : FAK was also shown to negatively regulate v-Src mediated phosphorylation of the FAK related kinase PYK2
Shah et al., Mol Pharmacol 2002 : Ang II increased the association of Pyk2 with Src and with the epidermal growth factor receptor (EGF-R)
Keogh et al., Biochem Biophys Res Commun 2002 : We have investigated the regulation of Pyk2 in human umbilical vein endothelial cells in response to GPCAs and show that ( 1 ) thrombin, a PAR-1 peptide, and histamine cause rapid concentration- and time dependent phosphorylation on tyrosines 402 ( Src kinase binding site ), 881 ( Grb2 binding site ), and 580 ( an autophosphorylation site ), ( 2 ) thrombin stimulated phosphorylation is dependent on intracellular calcium and independent of PKC and PI-3 kinase, and ( 3 ) inhibition of Src kinases has no significant effect on thrombin stimulated phosphorylation, implying that tyrosine phosphorylation of Pyk2 is independent of Src binding
Tai et al., Arterioscler Thromb Vasc Biol 2002 : Although flow induced Cas phosphorylation was inhibited by kinase-inactive Src, PYK2 activation induced by flow was not inhibited by overexpression of kinase-inactive Src
Seabold et al., J Biol Chem 2003 : The protein-tyrosine kinase Pyk2/CAKbeta/CADTK is a key activator of Src in many cells
Shi et al., J Biol Chem 2004 : Pyk2 is a member of the focal adhesion kinase family and can be activated by c-Src , epidermal growth factor receptor (EGFR), Janus kinase 1, tyrosine kinases, and G-protein coupled receptor signaling
Banno et al., J Biol Chem 2005 : Furthermore, we found that PLD2 was associated with Pyk2 and Src, and that activation of PLD2 was required for H ( 2 ) O ( 2 ) -enhanced association of Src with Pyk2 leading to full activation of Pyk2 ... This study is the first demonstration that PLD2 activation is implicated in Src dependent phosphorylation of Pyk2 ( Tyr ( 580 ) and Tyr ( 881 ) ) by promoting the complex formation between Pyk2 and activated Src in PC12 cells exposed to H ( 2 ) O ( 2 ), thereby resulting in activation of the survival signaling pathway PI3K/Akt/p70S6K
Riol-Blanco et al., J Immunol 2005 (MAP Kinase Signaling System) : Pyk2 activation was independent of G ( i ) and Src and was dependent on Rho
Clark et al., Regul Pept 2007 : Interestingly, inhibition of Pyk2 inhibited Ang II-induced Src activation suggesting that these two non-receptor tyrosine kinases may be acting in concert to mediate Ang II effects in astrocytes
Dewar et al., Mol Pharmacol 2007 (Calcium Signaling) : Neither EGFR kinase nor Pyk2 inhibition prevented Src activation ; however, inhibition of Src kinase activity prevented Pyk2 activation
Lin et al., Toxicol Appl Pharmacol 2008 : LPS stimulated Src, PYK2 , EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110
Zhang et al., BMC cancer 2008 (Adenocarcinoma...) : Transfection studies indicated that exogenous SOCS3 interacted with PYK2, and both the Src homology 2 (SH2) and the kinase inhibitory region (KIR) domains of SOCS3 contributed to PYK2 binding
Wong et al., Cell Signal 2011 : In these cells, Pyk2 phosphorylation was dependent on Src family kinase activity and required actin polymerisation, phosphatidylinositol-3 kinase and phospholipase C activity as well as extracellular calcium
Arpaia et al., Oncogene 2012 (Neoplasm Metastasis...) : Our data indicate that interaction between Cav1 and Rho-GTPases ( most likely RhoC but not RhoA ) promotes metastasis by stimulating a5-integrin expression and regulating the Src dependent activation of p130 ( Cas ) /Rac1, FAK/Pyk2 and Ras/Erk1/2 signaling cascades
Jeschke et al., J Biol Chem 1998 : These data indicate that osteoblastic cells express Pyk2 , which is tyrosine phosphorylated and activated in response to G protein activation by fluoroaluminate, and that the mechanism of Pyk2 activation most likely involves Src