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HIF1A — MMP1

Text-mined interactions from Literome

Luo et al., BJU Int 2006 (Neoplasm Invasiveness...) : The expression of E-cadherin, vimentin, cathepsin D, MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be regulated by HIF-1alpha in human prostate cancer cells
Shyu et al., Exp Cell Res 2007 (Adenocarcinoma...) : Mechanistic studies revealed that HIF-1alpha overexpression could increase the expression of uPAR and MMP1 , but not MMP2
Lin et al., FEBS Lett 2008 (Osteoarthritis) : Hypoxia-inducible factor-1alpha regulates matrix metalloproteinase-1 activity in human bone marrow derived mesenchymal stem cells ... In vitro invasion assays and quantitative PCR analyses showed that targeted inhibition of HIF-1alpha in bmMSC-1 decreased its invasion and expressions of MMP1 and MMP3, whereas overexpression of HIF-1alpha in bmMSC-5 increased its invasion and expressions of MMP1 and MMP3 ... Therefore, HIF-1alpha can regulate MMP1 and MMP3 expressions in human bmMSCs, which might suggest a pathophysiological role of bmMSC expressing high HIF-1alpha in bone diseases
Kang et al., Clin Exp Pharmacol Physiol 2009 (Diabetes Mellitus, Experimental...) : Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 alpha/VEGF and MMP/TIMP regulation and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes