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DMD — NOS2
Text-mined interactions from Literome
Gücüyener et al., Brain Dev 2000
(Cerebral Palsy...) :
Nitric oxide is formed in skeletal muscle by the neuronal type
nitric oxide synthase and the signalling function of
dystrophin and related compounds are in part
mediated by nitric oxide
Sander et al., Proc Natl Acad Sci U S A 2000
(Ischemia...) :
In both mouse and human skeletal muscle,
dystrophin deficiency
results in loss of neuronal
nitric oxide synthase , which normally is localized to the sarcolemma as part of the dystrophin-glycoprotein complex
Louboutin et al., Mol Med 2001
(Muscular Dystrophy, Animal...) :
iNOS expression in dystrophinopathies can be
reduced by somatic gene transfer of
dystrophin or utrophin
Thomas et al., PloS one 2012
(Disease Models, Animal...) :
In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD,
dystrophin deficiency
causes loss of neuronal
nitric oxide synthase ( nNOSµ ) from the sarcolemma, producing functional ischemia when the muscles are exercised