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CDKN1A — CDKN1B

Pathways - manually collected, often from reviews:

• BioCarta influence of ras and rho proteins on g1 to s transition: p21 (CDKN1A) → p27 (CDKN1B) (transcription, inhibits)
• Reactome Reaction: CDKN1A → CDKN1B (reaction) Montagnoli et al., Genes Dev 1999, Tsvetkov et al., Curr Biol 1999, Carrano et al., Nat Cell Biol 1999, Ganoth et al., Nat Cell Biol 2001, Bornstein et al., J Biol Chem 2003, Wang et al., Biochemistry 2005*, Mitra et al., Cell cycle (Georgetown, Tex.) 2006, Harper et al., Cell 1993*
• WikiPathways Association Between Physico-Chemical Features and Toxicity Associated Pathways: AKT1 → Complex of CDKN1A-CDKN1B (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of PKMYT1-CKS2-CCNB2-CKS1B-CCNA2-CDK1-CCNB1-CDKN1B-CDKN1A (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 15 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Ophid Interaction: CDKN1A — CDKN1B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CDKN1A — CDKN1B (aggregation, confirmational text mining) Gudas et al., Mol Cell Biol 1999*

Text-mined interactions from Literome

Steinman et al., Oncogene 2001 : Cell cycle independent upregulation of p27Kip1 by p21Waf1 in K562 cells ... For example, an increase in levels of the cdki p27Kip1 follows upregulation of p21Waf1 in several cell types induced to differentiate by diverse stimuli ... In this study, we have investigated whether p21Waf1 expression itself, rather than the differentiating agent, could be increasing p27Kip1 protein levels ... In K562 cells, upregulation of p27Kip1 by p21Waf1 during differentiation facilitated an ordered transition between these two cdki 's, each of which may distinctly influence the differentiation process
Suzuki et al., Hypertens Res 2002 (MAP Kinase Signaling System) : The results also indicated that the constitutive activation of Ras might have induced the persistent expression of p21cip1 and p27kip1 , and that this induction of p21cip1 and p27kip1 expression possibly caused the cell cycle arrest at the G1 phase
Sandhu et al., Mol Cell Biol 1997 : As cdk4- and cdk6 associated p15INK4B increased during TGF-beta arrest of sensitive cells, there was a loss of cyclin D1, p21Cip1 , and p27Kip1 from these kinase complexes, and cyclin E-cdk2 associated p27Kip1 increased
Kokontis et al., Mol Endocrinol 1998 (Prostatic Neoplasms) : At concentrations that repressed growth, androgen transiently induced the expression of the cyclin dependent kinase (cdk) inhibitor p21waf1/cip1 in 104-R1 cells, while expression of the cdk inhibitor p27Kip1 was persistently induced by androgen in both 104-R1 and 104-R2 cells