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CCNB1 — CDKN1A

Pathways - manually collected, often from reviews:

• BioCarta cell cycle: g2/m checkpoint: p21 (CDKN1A) → Cyclin B/CDC2 complex (CDC2-CCNB1) (modification, activates)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CDKN1A — CCNB1 Poon et al., J Biol Chem 1996
• IRef Bind_translation Interaction: CDKN1A — CCNB1 (coimmunoprecipitation) Poon et al., J Biol Chem 1996
• IRef Biogrid Interaction: CDKN1A — CCNB1 (physical association, affinity chromatography technology) Poon et al., J Biol Chem 1996
• IRef Biogrid Interaction: CDKN1A — CCNB1 (physical association, affinity chromatography technology) Amador et al., Mol Cell 2007*
• IRef Biogrid Interaction: CDKN1A — CCNB1 (direct interaction, pull down) Garcia-Wilson et al., Cell cycle (Georgetown, Tex.) 2005*
• IRef Biogrid Interaction: CDKN1A — CCNB1 (physical association, affinity chromatography technology) Ando et al., J Biol Chem 2001*
• MIPS CORUM Cell cycle kinase complex CDC2: Cell cycle kinase complex CDC2 complex (CCNB1-CCNB2-CCND1-CDK1-CDKN1A-PCNA) Zhang et al., Mol Biol Cell 1993
• IRef Corum Interaction: Complex of CCNB2-CDKN1A-CCNB1-PCNA-CDK1-CCND1 (association, anti bait coimmunoprecipitation) Zhang et al., Mol Biol Cell 1993
• IRef Hprd Interaction: CDKN1A — CCNB1 (in vivo) Poon et al., J Biol Chem 1996
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Ando et al., J Biol Chem 2001*
• IRef Intact Interaction: CDKN1A — CCNB1 (physical association, coimmunoprecipitation) Zhang et al., FEBS Lett 2004*
• IRef Intact Interaction: Complex of PKMYT1-CKS2-CCNB2-CKS1B-CCNA2-CDK1-CCNB1-CDKN1B-CDKN1A (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 15 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Ophid Interaction: CDKN1A — CCNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., Mol Pharmacol 1999 (Osteosarcoma) : p21 ( waf1 ) induction also inhibited the increased cyclin B1-associated kinase activity induced by paclitaxel
Fournel et al., Cancer Res 2002 (Colonic Neoplasms) : In correlation with its antitumor activity both in vitro and in vivo, Compound 2 induces expression of p21 ( WAF1/Cip1 ), gelsolin, and keratin 19, while down regulating expression of cyclin A and cyclin B1 in human cancer cells in a dose dependent manner
Charrier-Savournin et al., Mol Biol Cell 2004 : p21 Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress
Cheng et al., Cancer Sci 2004 (Carcinoma, Hepatocellular...) : Etodolac induced p21WAF1/Cip1 and p27Kip1 expression and inhibited CDK2, CDK4, CDC2, cyclin A and cyclin B1 expression, but did not affect cyclin D1 or cyclin E. HGF and 10 % FBS induced ERK phosphorylation, but phosphorylation of p38, JNK and AKT was down-regulated by etodolac
Cariveau et al., Anticancer Res 2005 : Data indicates that the induction of radiation induced division delay appears to be dependent on the p21 inhibition of cyclin B1 and, furthermore, p21 and cyclin B1 expression are highly dependent on cell density
Granada et al., Arterioscler Thromb Vasc Biol 2005 (Aortic Diseases) : The antiproliferative action of MMc was associated with a selective increase in the expression of the cyclin dependent kinase inhibitor p21 , and with a decrease in cyclin B1-cyclin dependent kinase-1 complex activity
Archer et al., Am J Physiol Gastrointest Liver Physiol 2005 (Colonic Neoplasms) : The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1 dependent mechanism in human colon cancer cells
Touny et al., Prostate 2006 (Adenocarcinoma...) : The G2/M cell-cycle arrest is one mechanism by which genistein exerts its anti-proliferative effects, and the proposed underlying causes encompass the transcriptional repression of cyclin B1 and the activation of p21
Li et al., Int J Oncol 2007 (Prostatic Neoplasms) : Propolis group 3 showed higher induction of p21 expression but no inhibition of cyclin D1, CDK4 and cyclin B1 expression
Chan et al., J Pathol 2008 (Carcinoma, Squamous Cell...) : This inhibitory phenomenon was associated with the reduced expressions of cyclin B1 , cyclinD1 and cdc25B but increased expression of p27 ( Kip1 ) and p21 ( Cip1 )
Gillis et al., Cell cycle (Georgetown, Tex.) 2009 : p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage ... Decreased levels of cyclin B1 in response to DNA damage seen in wild-type cells is due to p21 mediated degradation of cyclin B1 as this can be inhibited by a proteasomal inhibitor ... These results indicate that p21 mediated degradation of cyclin B1 in response to DNA damage is necessary for the maintenance of G ( 2 ) cell cycle arrest
Kuo et al., Mol Cancer Ther 2009 (Breast Neoplasms) : In contrast, DHE caused S-G ( 2 ) /M arrest by increasing p21 expression and chk1 activation and inhibiting cyclin A, cyclin B , cdc25A, and cdc25C expression in MDA-MB-231 cells
Ray et al., Cancer Res 2010 (Breast Neoplasms) : Further studies revealed that BME treatment enhanced p53, p21 , and pChk1/2 and inhibited cyclin B1 and cyclin D1 expression, suggesting an additional mechanism involving cell cycle regulation
Kim et al., Phytomedicine 2010 (Breast Neoplasms) : In addition, TPA induced down-regulation of cyclin B1 was inhibited by LY294002 ; however, the basal level of p21 was increased by TPA and TPA induced p21 expression was further increased by LY294002
Moon et al., Cell Mol Life Sci 2011 : In this process, p21 induces endoreduplication through the inhibition of cyclin E/Cdk2 activity at 24 h but does not directly regulate cyclin B1/Cdc2 activity
Li et al., J Virol 2011 : The reduction of Cdc2-cyclin B1 activity in HHV-6 infected cells was also partly due to the increased expression of the cell cycle-regulatory molecule p21 in a p53 dependent manner
Mateen et al., Epigenetics 2012 (Carcinoma, Non-Small-Cell Lung) : The enhanced p21 levels promoted proteasomal degradation of cyclin B1 , the limited supply of which halts the progression of cells into mitosis
Wang et al., Carcinogenesis 2013 (Carcinoma, Hepatocellular...) : OA induced G2/M cell cycle arrest through p21 mediated downregulation of cyclin B1/cdc2
Bates et al., Oncogene 1998 : Arrest of cells in G2 likely reflects an inability to induce cyclin B1/cdc2 kinase activity in the presence of p21Waf1/Cip1 , although the inefficient association of p21Waf1/Cip1 and cyclin B1 suggests that the mechanism of inhibition is indirect
Stewart et al., Mol Cell Biol 1999 : In contrast, loss of p21 did not lead to deregulated cyclin D1-dependent kinase activities, nor did p21 directly regulate cyclin B1/Cdc2 activity