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JUN — MPZ

Text-mined interactions from Literome

Gearan et al., Parkinsonism Relat Disord 2001 (Parkinson Disease, Secondary) : To assess the involvement of c-Jun, a key transcription factor substrate of SAPK ( also known as c-Jun N-terminal kinase, or JNK ) in the MPTP induced death of dopaminergic nigral neurons, we determined the ability of MPP+ , the active toxin metabolite of MPTP, to induce the phosphorylated form of c-Jun in dopaminergic neurons in nigral ( ventral mesencephalon ) cultures ... At a dose of MPP+ that specifically induces apoptotic changes in nuclear morphology in tyrosine hydroxylase positive ( dopaminergic ) cells in these cultures, MPP+ induces nuclear phospho-c-Jun immunoreactivity ( IR )
Sawada et al., Neuropharmacology 2002 (Parkinsonian Disorders) : MPP ( + ) treatment caused the upregulation of c-Jun amino-terminal kinase (JNK) and dopaminergic neuronal death, the latter being blocked by curcumin, an inhibitor of the c-Jun/AP-1 cascade
Pain et al., Toxicology 2008 : Our results showed that MPP ( + ) induced not only an activation of c-Jun but also an early and robust stimulation of caspase-9 in midbrain of rats